Comparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model

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dc.authoridMAKAV, MUSTAFA/0000-0003-1879-8180
dc.authoridEROGLU, Huseyin Avni/0000-0002-1040-3255
dc.authoridGok, Mustafa/0000-0001-7021-0984
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.authoridKARAYOL, SUNAY SIBEL/0000-0002-2696-3580
dc.contributor.authorAdali, Yasemen
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorMakav, Mustafa
dc.contributor.authorKarayol, Sunay Sibel
dc.contributor.authorGuvendi, Gulname Findik
dc.contributor.authorGok, Mustafa
dc.date.accessioned2025-01-27T20:49:57Z
dc.date.available2025-01-27T20:49:57Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractINTRODUCTION: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. METHODS: Thirty-six female Wistar albino rats, 4-6 months old, and weighing from 190 to 250 g, were used in this study. The animals were randomly divided into six equal groups: GI (control), G2 (tru-cut control), G3 (FNAC control), G4 (Alcoholic liver disease model), G5 (Alcoholic liver disease model + FNAC), and G6 (Alcoholic liver disease model + tru-cut biopsy). After a histopathological evaluation by light microscopy, the sensitivity, specificity, positive and negative predictive values of FNAC and tru-cut biopsy for the diagnosis of liver lesions were calculated. RESULTS: No pathology was detected in GI except for mild congestion. On the other hand, hepatocyte damage, periportal inflammation, congestion, and fatty changes were detected in all liver tissues of the alcoholic liver disease groups. The sensitivity of hepatocyte damage, inflammation, congestion, and fatty change parameters for FNAC were 33.3%, 80%, 0%, and 0%, respectively, while the sensitivity of the same variables for tru-cut were 66.7%, 40%, 100%, and 20%, respectively. DISCUSSION: Both techniques were superior in some aspects. FNAC can be an attractive alternative to tru-cut biopsy and applied in routine practice in the diagnosis of non-tumoral liver diseases.
dc.description.sponsorshipKafkas University [2016-TS-56]
dc.description.sponsorshipThis study is funded by Kafkas University (Project number: 2016-TS-56).
dc.identifier.doi10.1590/1806-9282.66.8.1030
dc.identifier.endpage1035
dc.identifier.issn1806-9282
dc.identifier.issue8
dc.identifier.pmid32935794
dc.identifier.scopus2-s2.0-85091052973
dc.identifier.scopusqualityQ2
dc.identifier.startpage1030
dc.identifier.urihttps://doi.org/10.1590/1806-9282.66.8.1030
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25367
dc.identifier.volume66
dc.identifier.wosWOS:000568954700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectLiver diseases, alcoholic
dc.subjectBiopsy, fine-needle
dc.subjectBiopsy
dc.subjectAspiration Biopsy
dc.titleComparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model
dc.typeArticle

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