Insulin resistance and pancreatic ? cell dysfunction are associated with thyroid hormone functions: A cross-sectional hospital-based study in Turkey

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dc.contributor.authorKocaturk, Evin
dc.contributor.authorKar, Ezgi
dc.contributor.authorKiraz, Zeynep Kusku
dc.contributor.authorAlatas, Ozkan
dc.date.accessioned2025-01-27T20:52:33Z
dc.date.available2025-01-27T20:52:33Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and aims: The prevalence of thyroid disease in diabetic patients is significantly higher than the general population. This indicates a possible interaction between thyroid functions and insulin sensitivity. This study aimed to investigate the relationship between insulin resistance (IR), pancreatic beta cell function, and thyroid function tests. Methods: This cross-sectional study was conducted with adults who applied to Eskisehir Osmangazi University Hospital for general control. Fasting insulin, glucose, TSH, fT3, and fT4 levels in the serum of 1340 adult (18-60 aged) patients without any chronic diseases were examined retrospectively. The fT3/fT4 ratio, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and HOMA-beta values were calculated. The correlation between HOMA-IR and HOMA-beta values with thyroid function tests and differences between hormone levels of patients with and without IR were evaluated. Results: There was a positive correlation between HOMA-IR and TSH, negative with fT4. Also, a positive correlation between HOMA-beta and fT3, negative correlation with fT4 were observed. In the IR group, fT3 levels were found significantly higher and fT4 levels were significantly lower. TSH levels were higher in the IR group but not statistically significant. The fT3/fT4 ratio was found significantly higher in the IR group and was correlated positively with both HOMA-IR and HOMA-beta. Conclusion: Our results revealed that thyroid dysfunction prevalence is quite high in adults who have not yet been diagnosed with diabetes but have insulin resistance and the onset of pancreatic beta cell dysfunction. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.dsx.2020.11.008
dc.identifier.endpage2151
dc.identifier.issn1871-4021
dc.identifier.issn1878-0334
dc.identifier.issue6
dc.identifier.pmid33395774
dc.identifier.scopus2-s2.0-85096499625
dc.identifier.scopusqualityQ1
dc.identifier.startpage2147
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2020.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25792
dc.identifier.volume14
dc.identifier.wosWOS:000604402500012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofDiabetes & Metabolic Syndrome-Clinical Research & Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectInsulin resistance
dc.subjectThyroid function tests
dc.subjectPrevalence
dc.subjectDiabetes mellitus
dc.subjectThyroid diseases
dc.titleInsulin resistance and pancreatic ? cell dysfunction are associated with thyroid hormone functions: A cross-sectional hospital-based study in Turkey
dc.typeArticle

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