Elevated circulating nitric oxide levels correlates with enhanced oxidative stress in patients with hyperemesis gravidarum

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dc.authoridHalici-Ozturk, Filiz/0000-0002-4494-5167
dc.contributor.authorBeyazit, Fatma
dc.contributor.authorTurkon, Hakan
dc.contributor.authorPek, Eren
dc.contributor.authorOzturk, Filiz Halici
dc.contributor.authorUnsal, Mesut
dc.date.accessioned2025-01-27T20:35:05Z
dc.date.available2025-01-27T20:35:05Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSince the biochemical and molecular mechanisms responsible for ongoing oxidative stress in hyperemesis gravidarum (HEG) patients have not yet been fully elucidated, the aim of this study was to evaluate the possible role of nitric oxide (NO), malondialdehyde (MDA) and other oxidative stress markers in the disease pathophysiology. Moreover, the relation between oxidative stress markers and Helicobacter pylori (H. pylori) infection was also investigated. Women with pregnancies complicated by HEG (n=33) were compared with pregnant women without HEG (n=30) and with healthy non-pregnant women (n=31). Serum NO, MDA, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and H. pylori infection status were determined for each subject. Serum NO levels and OSI index were found to be increased (p=.001 and .013, respectively) and TAS levels were decreased (p<.001) in HEG patients compared with both controls regardless of H. pylori infection status. Serum MDA and TOS levels were not different between the study groups. Helicobacter pylori infection rates were similar in each group. The reduced antioxidant activities, as well as the increased OSI and NO levels in HEG patients indicate possible oxidative stress conditions in HEG patients. Moreover, serum NO levels may be used as an adjunctive marker to distinguish HEG patients from other causes of emesis during pregnancy.Impact statementWhat is already known on this subject? Current evidence suggests that oxidative stress is a significant factor responsible for a number of complications during pregnancy.What do the results of this study add? Hyperemesis gravidarum is an oxidative stress condition, as reflected by increased nitric oxide (NO) and decreased total antioxidant status activity, regardless of H. Pylori infection.What are the implications for clinical practice and/or further research? Full disclosure of the association between circulating NO and hyperemesis gravidarum would shed light on underlying biological mechanisms and could help clinical management of similar pregnancy-associated morbidity states.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [916]
dc.description.sponsorshipThis research is supported by The Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University as Independent Research Project (Project ID: 916).
dc.identifier.doi10.1080/01443615.2017.1383371
dc.identifier.endpage673
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue5
dc.identifier.pmid29390905
dc.identifier.scopus2-s2.0-85041625643
dc.identifier.scopusqualityQ3
dc.identifier.startpage668
dc.identifier.urihttps://doi.org/10.1080/01443615.2017.1383371
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23563
dc.identifier.volume38
dc.identifier.wosWOS:000436441700014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHyperemesis gravidarum
dc.subjectoxidative stress
dc.subjectnitric oxide
dc.titleElevated circulating nitric oxide levels correlates with enhanced oxidative stress in patients with hyperemesis gravidarum
dc.typeArticle

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