The relationship between C-reactive protein rs3091244 polymorphism and ankylosing spondylitis

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dc.authoridZateri, Coskun/0000-0002-7948-5383
dc.contributor.authorAkbal, Ayla
dc.contributor.authorResorlu, Hatice
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorSavas, Yilmaz
dc.contributor.authorZateri, Coskun
dc.contributor.authorSargin, Betul
dc.contributor.authorBozkurt, Emre
dc.date.accessioned2025-01-27T20:31:49Z
dc.date.available2025-01-27T20:31:49Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAimsPrevious studies have shown that C-reactive protein (CRP) gene polymorphism can be related to inflammatory changes. The present study aimed to examine the association between CRP gene polymorphism and clinical and laboratory findings in ankylosing spondylitis (AS) patients. Materials and methodsA total of 80 patients, 40 with AS and 40 controls, were included in the study. Diagnosis of AS was made according to Assessment in AS International Working Group criteria. Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Radiology Index scores were evaluated. CRP gene C, A and T alleles were evaluated and were determined using the analysis of melting curves after real time polymerase chain reaction. The odds ratios were calculated for all alleles and haploids of the CRP gene. We investigated the relationship between the CRP polymorphism and clinical and laboratory findings. ResultsA, C, T allele frequencies in the control group were 15%, 57.5% and 27.5%. The allele frequencies in the AS group were 38%, 68.8% and 26.2%. While C and T allele frequencies were shown to be similar in the two groups, A allele frequency was higher in the AS group compared to the control group. The CC wild allele was 42.5% in the control group and 47.5% in the AS group (P = 1.0). Odds ratios for the C allele were 1.6, for the CC haploid 1.2 and for the CT haploid 3.7. Chest expansion and finger-to-ground distance was better in the CRP gene polymorphism group compared to the no polymorphism group. ConclusionThe presence of the CRP gene CC wild haploid and C allele in patients may indicate an increased risk for AS.
dc.identifier.doi10.1111/1756-185X.12619
dc.identifier.endpage48
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue1
dc.identifier.pmid26480896
dc.identifier.scopus2-s2.0-84956597148
dc.identifier.scopusqualityQ3
dc.identifier.startpage43
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12619
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23278
dc.identifier.volume19
dc.identifier.wosWOS:000369789300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectankylosing spondylitis
dc.subjectclinical severity
dc.subjectCRP gene polymorphism
dc.titleThe relationship between C-reactive protein rs3091244 polymorphism and ankylosing spondylitis
dc.typeArticle

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