Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties

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dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSağbaş, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSılan, Coşkun
dc.contributor.authorAktaş, Nahit
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2025-01-27T21:01:38Z
dc.date.available2025-01-27T21:01:38Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90 degrees C for 2 h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5 degrees C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [113Z238]
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (113Z238).
dc.identifier.doi10.1016/j.ijbiomac.2015.10.057
dc.identifier.endpage159
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid26526171
dc.identifier.scopus2-s2.0-84951767677
dc.identifier.scopusqualityQ1
dc.identifier.startpage150
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2015.10.057
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27134
dc.identifier.volume82
dc.identifier.wosWOS:000367425100020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTannic acid
dc.subjectAntimicrobial/antioxidant hydrogel
dc.subjectBiodegradable/biocompatible superporous film
dc.titleBiocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties
dc.typeArticle

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