Association Between Resistin Level and Renal Function in Patients Undergoing Coronary Artery Bypass Graft Surgery

Basit Öğe Kaydı
dc.authoridAyik, Mehmet Fatih/0000-0002-0780-3047
dc.contributor.authorGungor, Hasan
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorZorlu, Ali
dc.contributor.authorOguz, Emrah
dc.contributor.authorAyik, Mehmet Fatih
dc.contributor.authorKumak, Ferhat
dc.contributor.authorZoghi, Mehdi
dc.date.accessioned2025-01-27T20:32:07Z
dc.date.available2025-01-27T20:32:07Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: Thirty-seven consecutive patients (mean +/- SD, age 60 +/- 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL. Results: Mean + SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 +/- 4.2 ng/mL, 78 +/- 25 mL/min per 1.73 m(2), 42 +/- 14 mg/dL, and 1.08 +/- 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r = -0.398; P = 0.015), statin usage (r = -0.393; P = 0.016), and A-blocker usage (r = -0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m(2), with 100% sensitivity and 61.1% specificity. Conclusion: The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery.
dc.identifier.endpage887
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue6
dc.identifier.pmid22534631
dc.identifier.scopus2-s2.0-84864622307
dc.identifier.scopusqualityQ2
dc.identifier.startpage883
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23354
dc.identifier.volume60
dc.identifier.wosWOS:000306851700020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcoronary artery bypass graft surgery
dc.subjectrenal function
dc.subjectresistin
dc.titleAssociation Between Resistin Level and Renal Function in Patients Undergoing Coronary Artery Bypass Graft Surgery
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu