L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats

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dc.contributor.authorTas, Sukru
dc.contributor.authorOzkan, Omer Faruk
dc.contributor.authorCikman, Oztekin
dc.contributor.authorKiraz, Asli
dc.contributor.authorAkgun, Yilmaz
dc.contributor.authorKaraayvaz, Muammer
dc.date.accessioned2025-01-27T20:54:09Z
dc.date.available2025-01-27T20:54:09Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: To evaluate histopathologically the radioprotective effect of L-carnitine on the colonic mucosa in rats undergoing abdominopelvic irradiation. METHODS: Thirty-two rats were randomly assigned to four experimental groups: intraperitoneal administration of normal saline (group 1) or L-carnitine (300 mL/kg; group 2), followed in groups 3 and 4, respectively, by one dose of abdominopelvic radiation (20 Gy) 30 min later. Rats were sacrificed 5 days after radiation, and their descending colons were resected for histopathological evaluation of the presence and severity of damage. RESULTS: Average damage scores did not differ significantly between groups 1 and 2 (0.13 +/- 0.35 and 0.25 +/- 0.46, respectively); the group 3 score was highest (10.25 +/- 0.71), and the group 4 score (3.63 +/- 1.41) was significantly lower than that of group 3 (both p = 0.0001). Pre-radiation L-carnitine administration significantly reduced mucosal thinning, crypt distortion, reactive atypia, inflammation, cryptitis, and reactive lymph-node hyperplasia (all p < 0.01). CONCLUSIONS: L-carnitine had a radioprotective effect on rat colonic mucosa. L-carnitine use should be explored for patients with gastrointestinal cancer, who have reduced serum L-carnitine levels.
dc.identifier.doi10.1590/S0102-865020160090000007
dc.identifier.endpage620
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue9
dc.identifier.pmid27737347
dc.identifier.scopus2-s2.0-84992146098
dc.identifier.scopusqualityQ2
dc.identifier.startpage615
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160090000007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25995
dc.identifier.volume31
dc.identifier.wosWOS:000391431800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCarnitine
dc.subjectRadiation
dc.subjectColitis
dc.subjectRadiation-Protective Agents
dc.subjectRats
dc.titleL-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats
dc.typeArticle

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