308G/A and 238G/A polymorphisms in the TNF-? gene may not contribute to the risk of arthritis among Turkish psoriatic patients

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorIsik, Selda
dc.contributor.authorSılan, Fatma
dc.contributor.authorKilic, Sevilay
dc.contributor.authorHiz, Meliha Merve
dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T21:01:32Z
dc.date.available2025-01-27T21:01:32Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Tumor necrosis factor-alpha (TNF-alpha) is an important proinflammatory cytokine playing a key role in the pathogenesis of psoriasis (Ps) and psoriatic arthritis (PsA). TNF alpha gene promoter region single nucleotide polymorphisms (SNPs) affect the clinical course, severity and the response to the treatment. Aim of the work: To find out whether TNF-alpha-238G/A and -308G/A promoter polymorphism in Ps patients increases arthritis risk. Patients and methods: The study included 129 psoriatic patients (71 with psoriasis only and 58 with PsA). Two single nucleotide polymorphisms in the TNF alpha gene promoter region (238G/A and -308G/A) were genotyped by real-time polymerase chain reaction. Results: Ps patients without arthritis had a mean age of 44.20 +/- 13.85 years (range 18-68 years), while PsA patients had a mean age of 49.15 +/- 13.47 years (range 18-82 years) and presented by dactylitis (67.2%), enthesitis (62.1%) followed by spondylitis (60.3%). Periosteal reaction was present in 19%. The psoriatic arthritis severity index (PASI) was comparable between those with (8.2 +/- 7.1) and without (7.3 +/- 5.12.1) arthritis. The allele positivity of TNF-238A and -308A was not associated with the risk of arthritis among psoriatic patients (OR: 1.002; 95% CI: 0.38-2.6, p=0.99 and OR: 1.27; 95% CI: 0.51-3.2, p=0.6, respectively). In addition, none of the genotypes of the studied TNF-alpha polymorphisms were significantly associated with arthritis. Only spondylitis was significantly associated more frequently with the GG (67.3%) than the GA (22.2%) TNF-alpha-308G/A genotype (p=0.02). Conclusion: None of the haplotypes nor alleles of TNF-alpha-238G/A and -308G/A polymorphisms were significantly associated with arthritis development among psoriatic patients. (C) 2016 Egyptian Society of Rheumatic Diseases. Publishing services provided by Elsevier B.V.
dc.identifier.doi10.1016/j.ejr.2016.02.005
dc.identifier.endpage317
dc.identifier.issn1110-1164
dc.identifier.issn2090-2433
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84962172865
dc.identifier.scopusqualityQ3
dc.identifier.startpage313
dc.identifier.urihttps://doi.org/10.1016/j.ejr.2016.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27084
dc.identifier.volume38
dc.identifier.wosWOS:000408991700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofEgyptian Rheumatologist
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPsoriasis
dc.subjectPsoriatic arthritis
dc.subjectTNF-alpha-308G/A promoter polymorphism
dc.subjectTNF-alpha-238G/A promoter polymorphism
dc.subjectTumor necrosis factor (TNF alpha)
dc.subjectPASI
dc.title308G/A and 238G/A polymorphisms in the TNF-? gene may not contribute to the risk of arthritis among Turkish psoriatic patients
dc.typeArticle

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