Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model

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dc.authoridkaraboga, ihsan/0000-0001-6708-1229
dc.authoridPOLAT, ELIF/0000-0001-6808-5467
dc.authoridCELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.authoridYILMAZ, AHSEN/0000-0002-2270-2965
dc.contributor.authorDuran, Yasin
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorPolat, Fatin Rustu
dc.contributor.authorPolat, Elif
dc.contributor.authorErboga, Zeynep Fidanol
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorOztopuz, Rahime Ozlem
dc.date.accessioned2025-01-27T20:49:43Z
dc.date.available2025-01-27T20:49:43Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the study was to investigate traditionally used Royal Jelly (RJ) for treating an ethanol-induced gastric ulcer model in rats. A total of 32 Wistar albino male rats were divided into 4 groups of 8: group I = Control, group II = Ethanol, group III = RJ + Ethanol, and group IV = Lansoprazole + Ethanol. In groups II, III, and IV, animals were administered 1 ml of absolute ethanol orally after a 24-h fast to induce ulcer formation. The histopathological changes in the gastric mucosa were determined using hematoxylin-eosin (H&E) staining. Immunohistochemically, inducible nitric oxide (iNOS) and nuclear factor kappa beta (Nf-kappa beta) markings were evaluated in gastric tissue. Cell death in the gastric mucosa was determined by the TUNEL method. Oxidative status markers, superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), and myeloperoxidase (MPO) levels were determined spectrophotometrically. Expression of the interleukin - 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) genes in gastric tissues was determined by real-time PCR; and TNF-alpha, IL-10, and IL-1 beta levels were determined. RJ was found to inhibit iNOS and Nf-kappa beta activity in the gastric mucosa and prevent epithelial cell apoptosis. In particular, pro-inflammatory cytokines TNF-alpha and IL-1 beta levels were significantly decreased in the RJ + Ethanol group compared to the Ethanol group. In addition, a decrease in the MPO level indicated that RJ prevented tissue damage, especially by preventing inflammatory cell infiltration. The study demonstrated a possible gastroprotective effect of RJ in a rat ethanol-induced gastric ulcer model.
dc.description.sponsorshipResearch Fund of the Tekirda Namk Kemal University [NKUBAP.02, 18.181]
dc.description.sponsorshipThis work was supported by the Research Fund of the Tekirda Namk Kemal University. Project Number: NKUBAP.02.GA.18.181.
dc.identifier.doi10.1007/s11033-020-05939-w
dc.identifier.endpage8879
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue11
dc.identifier.pmid33135128
dc.identifier.scopus2-s2.0-85094844653
dc.identifier.scopusqualityQ2
dc.identifier.startpage8867
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05939-w
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25292
dc.identifier.volume47
dc.identifier.wosWOS:000584364400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectRoyal Jelly
dc.subjectGastric ulcer
dc.subjectInducible nitric oxide synthase
dc.subjectNuclear factor-kappa beta
dc.subjectApoptosis
dc.titleRoyal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model
dc.typeArticle

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