Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats

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dc.contributor.authorCikman, Oztekin
dc.contributor.authorSoylemez, Omer
dc.contributor.authorOzkan, Omer Faruk
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorSayar, Ilyas
dc.contributor.authorAdemoglu, Serkan
dc.contributor.authorTaysi, Seyithan
dc.date.accessioned2025-01-27T20:57:51Z
dc.date.available2025-01-27T20:57:51Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to investigate the possible protective role of antioxidant treatment with syringic acid (SA) on L-arginine-induced acute pancreatitis (AP) using biochemical and histopathologic approaches. A total of 30 rats were divided into 3 groups. The control group received normal saline intraperitoneally. The AP group was induced by 3.2 g/kg body weight L-arginine intraperitoneally, administered twice with an interval of 1 hour between administrations. The AP plus SA group, after having AP induced by 3.2 g/kg body weight L-arginine, was given SA (50 mg kg(-1)) in 2 parts within 24 hours. The rats were killed, and pancreatic tissue was removed and used in biochemical and histopathologic examinations. Compared with the control group, the mean pancreatic tissue total oxidant status level, oxidative stress index, and lipid hydroperoxide levels were significantly increased in the AP group, being 30.97 +/- 7.13 (P < 0.05), 1.76 +/- 0.34 (P < 0.0001), and 19.18 +/- 4.91 (P < 0.01), respectively. However, mean total antioxidant status and sulfhydryl group levels were significantly decreased in the AP group compared with the control group, being 1.765 +/- 0.21 (P < 0.0001) and 0.21 +/- 0.04 (P < 0.0001), respectively. SA reduces oxidative stress markers and has antioxidant effects. It also augments antioxidant capacity in L-arginine-induced acute toxicity of pancreas in rats.
dc.identifier.doi10.9738/INTSURG-D-14-00170.1
dc.identifier.endpage896
dc.identifier.issn0020-8868
dc.identifier.issue5
dc.identifier.pmid26011211
dc.identifier.scopus2-s2.0-84974815723
dc.identifier.scopusqualityQ4
dc.identifier.startpage891
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-14-00170.1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26528
dc.identifier.volume100
dc.identifier.wosWOS:000355193300019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt College Of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute pancreatitis
dc.subjectSyringic acid
dc.subjectTotal oxidant status
dc.subjectTotal antioxidant status
dc.titleAntioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats
dc.typeArticle

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