Quartz tuning fork biosensor: A potential tool for SARS-CoV-2 detection

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dc.authoridOZKAN, Sibel/0000-0001-7494-3077
dc.authoridUNAL, Mehmet Altay/0000-0001-8607-5043
dc.authoridARI, Fikret/0000-0002-6104-4467
dc.contributor.authorKavacik, Mehmet
dc.contributor.authorInce, Bahar
dc.contributor.authorAri, Fikret
dc.contributor.authorUnal, Mehmet Altay
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2025-01-27T20:11:46Z
dc.date.available2025-01-27T20:11:46Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPortable, fast, and practical devices are important in the fight against epidemic diseases. The lack of readily available small-scale commercial solutions prompted us to delve deeper into this research effort. Investment in Quartz Tuning Fork (QTF)-based biosensor research is significant due to its seamless integration with miniaturised and portable devices. Within the scope of this study, a new, cost-effective, and versatile frequency analyser designed for detecting diseases, compatible with screens of different sizes, has been introduced. The modified QTF sensor occured mass-sensitive SARS-CoV-2 nucleocapsid protein (SARS-NP) detection with remarkable simplicity, sensitivity, and selectivity. The developed QTF-based biosensor has an impressive linear detection range ranging from 5 to 200 ng/mL and an exceptionally low limit of detection (LOD) value of 1.72 ng/ mL. The sensitivity of the developed QTF-based biosensor was obtained as 50 Hz/1 mu M. The biosensor response was then evaluated in commercial human serum sample. After 15 days of storage, these biosensors retained approximately 93.7 % of their initial activity. Additionally, a Scanning Electron Microscope (SEM) and Atomic Force Microscope (AFM) comprehensively characterised the electrode surface.
dc.description.sponsorshipScientific and Technological Research Council of Canakkale Onsekiz Mart University [FIA-2020-3304]
dc.description.sponsorshipThe authors are grateful to the financial assistance from The Scientific and Technological Research Council of Canakkale Onsekiz Mart University, (FIA-2020-3304) .
dc.identifier.doi10.1016/j.microc.2023.109498
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85174634104
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2023.109498
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20717
dc.identifier.volume195
dc.identifier.wosWOS:001104579900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCOVID-19
dc.subjectQuartz Tuning Fork
dc.subjectQTF
dc.subjectSARS-CoV-2
dc.subjectBiosensor
dc.subjectImmunosensor
dc.titleQuartz tuning fork biosensor: A potential tool for SARS-CoV-2 detection
dc.typeArticle

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