Resveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension

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dc.authoridCabuk, Ali Kemal/0000-0001-5549-3744
dc.authoridgungor, buket/0000-0002-5802-1635
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorAydin, Mehmet
dc.contributor.authorGungor, Buket
dc.contributor.authorAkdur, A. Secil
dc.contributor.authorAksulu, Hakki Engin
dc.contributor.authorSılan, Coşkun
dc.contributor.authorSusam, Ibrahim
dc.contributor.authorCabuk, Ali Kemal
dc.date.accessioned2025-01-27T20:49:45Z
dc.date.available2025-01-27T20:49:45Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Inhibition of nitric oxide synthase (NOS) is a well-known experimental model of hypertension (HT). It was shown that oxidative stress contributes to the pathogenesis of HT. Resveratrol is a potent anti-oxidant that is found in red grapes, peanuts and red wine. It improves the NO response and increases endothelial NOS expression, which causes endothelium-dependent vasorelaxation as well as renal vasodilation. We aimed to explore the effects of resveratrol on blood pressure, the water-salt balance and sodium excretion as a reflection of renal function in NOS-inhibited rat models. Methods: Thirty-five male Sprague-Dawley rats (200-250 g) were used in this study. In order to obtain hypertension models, an NOS inhibitor, N-nitro-L-arginin (L-NNA) was used. The rats were randomly divided into five groups: controls (given water and 0.8% salty diet) and four groups [given L-NNA, resveratrol (RSV) eluent, RSV, and L-NNA + RSV]. Blood pressures were measured indirectly by the tail-cuff method on the first, seventh and 10th days. At the end of the study protocol (10th day), fluid balance, glomerular filtration rate, fractional sodium excretion, and blood and urine sodium and creatinine levels were measured. Results: At the end of the study protocol, blood pressures were higher in only the L-NNA group (117.8 +/- 3.5 vs 149.5 +/- 2.1 mmHg; p < 0.05), as expected. Additional applications of RSV with L-NNA could not prevent the increase in blood pressure (122.8 +/- 7.3 vs 155.4 +/- 4.4 mmHg; p < 0.05). There were no remarkable changes in water-salt balance and renal function with the application of resveratrol. Conclusion: Resveratrol was unable to prevent or reverse blood pressure increase in NOS-inhibited rats.
dc.description.sponsorshipCanakkale Onsekiz Mart University [2010/069]
dc.description.sponsorshipThis work was supported by Research Fund of the Canakkale Onsekiz Mart University; project number: 2010/069
dc.identifier.doi10.5830/CVJA-2016-069
dc.identifier.endpage146
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue3
dc.identifier.pmid28759085
dc.identifier.scopus2-s2.0-85022005806
dc.identifier.scopusqualityQ3
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.5830/CVJA-2016-069
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25302
dc.identifier.volume28
dc.identifier.wosWOS:000405948700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecthypertension
dc.subjectNOS
dc.subjectresveratrol
dc.subjectanti-oxidant
dc.subjectsodium excretion
dc.titleResveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension
dc.typeArticle

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