Synthesis, photophysical, electrochemical and morphological properties of a novel cross-linked chitosan-based fluorescent polymer: A fluorescence sensor for single-stranded DNA

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dc.authoridICIL, HURIYE/0000-0002-3389-6734
dc.authoridAltinisik, Sinem/0000-0003-0238-0169
dc.authoridAbourajab, Arwa/0000-0003-3122-9513
dc.authoridM Rashid, Rebwar/0009-0009-7561-852X
dc.authoridKoyuncu, Sermet/0000-0001-8352-8326
dc.contributor.authorYucekan, Ilke
dc.contributor.authorDinleyici, Meltem
dc.contributor.authorTemurlu, Selin
dc.contributor.authorRashid, Rebwar
dc.contributor.authorBodapati, Jagadeesh B.
dc.contributor.authorAl-Khateeb, Basma
dc.contributor.authorAbourajab, Arwa
dc.date.accessioned2025-01-27T20:49:28Z
dc.date.available2025-01-27T20:49:28Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis report details the first-time use of the perylene-3,4,9,10-tetracarboxylic dianhydride as a cross-linker to synthesize a novel fluorescent, chitosan-based cross-linked polymer (3). The polymer has single-stranded DNA (ssDNA) binding properties that can be used in sensor production for detecting salmon sperm DNA. Chitosan polymer's solubility is poor and restricted to only acidic media. In contrast, this new fluorescent chitosan polymer was soluble in various organic solvents and aqueous solutions at different pHs. Its absorption, photo physical, electrochemical and morphological properties were investigated in detail. Gel permeation chromatography determined the weight average molecular mass (Mw) of polymer 3 as 21300 g/mol. Seventeen hydrophobic perylene units were determined in the cross-linked network. The energy levels of the highest occupied molecular orbitals and lowest unoccupied molecular orbitals of the new polymer 3 were calculated as-6.24 and-3.96 eV, corresponding to the band gap of 2.28 eV. Fluorescence and ultraviolet spectroscopy techniques were used to study the interaction between ssDNA and polymer 3. The interaction pointed to the intercalative mode, and the cross-linked chitosan can be used as a stable and sensitive platform for ssDNA detection. These results show a new class of organic biopolymers that could yield promising potential in many biomedical applications.
dc.identifier.doi10.1016/j.eurpolymj.2023.112306
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85165489588
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2023.112306
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25171
dc.identifier.volume196
dc.identifier.wosWOS:001048888300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofEuropean Polymer Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPerylene cross-linker
dc.subjectChitosan
dc.subjectssDNA
dc.subjectFluorescence
dc.subjectMorphology
dc.titleSynthesis, photophysical, electrochemical and morphological properties of a novel cross-linked chitosan-based fluorescent polymer: A fluorescence sensor for single-stranded DNA
dc.typeArticle

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