Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer

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dc.authoridSerin, Kursat Rahmi/0000-0001-9023-9151
dc.contributor.authorVarol, Basak
dc.contributor.authorCoskun, Ozlem
dc.contributor.authorKarabulut, Senem
dc.contributor.authorSerin, Kursat Rahmi
dc.contributor.authorAsoglu, Oktar
dc.contributor.authorAlbeniz, Isil
dc.contributor.authorTas, Faruk
dc.date.accessioned2025-01-27T20:27:36Z
dc.date.available2025-01-27T20:27:36Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (p < 0.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (p = 0.05, p = 0.001), stage of disease (p < 0.001, p < 0.001), serum CEA level (p < 0.001, p < 0.001), and site of lesion (p < 0.001, p < 0.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (p < 0.001, p < 0.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.
dc.identifier.doi10.1007/s13277-014-1735-1
dc.identifier.endpage5582
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue6
dc.identifier.pmid24535779
dc.identifier.scopus2-s2.0-84904721173
dc.identifier.scopusqualityQ3
dc.identifier.startpage5575
dc.identifier.urihttps://doi.org/10.1007/s13277-014-1735-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22732
dc.identifier.volume35
dc.identifier.wosWOS:000337094900066
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTumor Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectColorectal cancer
dc.subjectADP-ribosylation
dc.subjectNAD glycohydrolase activity
dc.subjectSerum
dc.titleClinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer
dc.typeArticle

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