Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus

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dc.contributor.authorCakina, Suat
dc.contributor.authorAydin, Buket
dc.contributor.authorBeyazit, Fatma
dc.date.accessioned2025-01-27T20:49:45Z
dc.date.available2025-01-27T20:49:45Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disuplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [TSA2019-3096]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit, Project number: TSA2019-3096.
dc.identifier.doi10.1080/09513590.2020.1769062
dc.identifier.endpage1009
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue11
dc.identifier.pmid32436414
dc.identifier.scopus2-s2.0-85085519037
dc.identifier.scopusqualityQ2
dc.identifier.startpage1006
dc.identifier.urihttps://doi.org/10.1080/09513590.2020.1769062
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25301
dc.identifier.volume36
dc.identifier.wosWOS:000537937100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOxidative stress
dc.subjectthiol
dc.subjectdisulfide homeostasis
dc.subjectgestational diabetes mellitus
dc.titleEvaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus
dc.typeArticle

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