Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome

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dc.authoridaksoy, selma/0000-0001-5139-1791
dc.authoridOZTURK, Samil/0000-0002-9435-8139
dc.authoridCAKINA, SUAT/0000-0002-3990-7641
dc.contributor.authorCakina, Suat
dc.contributor.authorYucel, Selma
dc.contributor.authorPolat, Cemre Cagan
dc.contributor.authorOzturk, Samil
dc.date.accessioned2025-01-27T20:49:53Z
dc.date.available2025-01-27T20:49:53Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The restless legs syndrome is more frequent and critical in Multiple Sclerosis patients, and it harms their general well-being and life quality. Alpha-synuclein is a synuclein protein that can have an impact on the pathway of signaling, affecting the Dopamin 2 receptor and its receptor trafficking. Studies have shown that the decrease in dopamine 2 receptor and Restless Legs Syndrome disease are correlated. This study is aimed to ascertain the alpha-synuclein level in multiple sclerosis patients with restless legs syndrome. Materials and Methods: We took blood samples from 40 multiple sclerosis patients and 20 healthy individuals. Half of the patient group had Multiple Sclerosis with restless leg syndrome. In the study groups, the alpha-synuclein level was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-dependent immunosorbent assay (ELISA). Results: Alpha-synuclein gene expression level was found or be significantly lower in restless leg syndrome patients with multiple sclerosis than the Alpha-synuclein gene expression level in the control group. Conclusion: Alpha-synuclein may have an impact on the pathogenesis of the restless leg syndrome of multiple sclerosis disease. Further investigations are required to determine the impact of alpha-synuclein in the pathogenesis of restless leg syndrome in multiple sclerosis disease.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [TSA-2018-1414]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit, Project number: TSA-2018-1414.
dc.identifier.doi10.17826/cumj.674564
dc.identifier.endpage567
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.startpage562
dc.identifier.trdizinid385301
dc.identifier.urihttps://doi.org/10.17826/cumj.674564
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/385301
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25347
dc.identifier.volume45
dc.identifier.wosWOS:000537976000022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectRestless leg syndrome
dc.subjectmultiple sclerosis
dc.subjectalpha-synuclein
dc.subjectqRT-PCR
dc.subjectgene expression
dc.titleAlpha-synuclein levels in multiple sclerosis patients with restless leg syndrome
dc.typeArticle

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