Evaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC

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dc.contributor.authorUstun, Funda
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorAltaner, Semsi
dc.contributor.authorTuncbilek, Nermin
dc.contributor.authorUzal, Cem
dc.contributor.authorBerkarda, Sakir
dc.date.accessioned2025-01-27T20:50:25Z
dc.date.available2025-01-27T20:50:25Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBreast cancer is the leading cause of death among women, and morphine is used to relieve the pain of patients with cancer. The data on the effects of morphine on tumour growth and angiogenesis are contradictory. We determined in mouse breast cancer model whether analgesic doses of morphine would affect tumour angiogenesis, and then the correlation between microvessel density (MVD), Doppler sonography (DS) and Tc-99m-Tetrofosmin (TF) uptake. Ehrlich ascites tumour cell xenografts, Pgp-negative tumour were divided into two groups: (a) Morphine sulphate [0.714 mg/kg/day (equivalent to 50 mg per day for a 70 kg human)], (b) no-morphine. For the determination of angiogenesis in mice tumour tissue, TF scintigraphy, microvessel density and DS were done. MVD was significantly different between groups (49.4 +/- 1.8 vs. 41.8 +/- 1.9, morphine and no-morphine groups, respectively, P < 0.001). A strong correlation was found between late uptakes of mass at scintigraphy and degree of angiogenesis in histopathologic examination (r = 0.52, P < 0.01). There was statistically significant inverse correlation between degree of angiogenesis in histopathologic examination and washout ratio of TF (r = 0.40, P < 0.05). The higher values for angiogenesis are related to higher TF reuptake. There was no statistically significant correlation between DS and TF. A strong correlation was found between MVD and grade of DS (r = 0.51, P < 0.01). Our preclinical mice study indicates that morphine at clinically relevant doses stimulates angiogenesis, and angiogenesis triggered of morphine is demonstrated with MVD and DS, but not TF. However, uptake and washout of TF are compared with immunohistochemically assessed morphine-stimulated angiogenesis in tumour tissue.
dc.description.sponsorshipTrakya University (TUBAP) [615]
dc.description.sponsorshipThis study was supported by Trakya University Research Fund (TUBAP) no. 615.
dc.identifier.doi10.1007/s12032-010-9573-5
dc.identifier.endpage1272
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue4
dc.identifier.pmid20567944
dc.identifier.scopus2-s2.0-80052365486
dc.identifier.scopusqualityQ2
dc.identifier.startpage1264
dc.identifier.urihttps://doi.org/10.1007/s12032-010-9573-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25489
dc.identifier.volume28
dc.identifier.wosWOS:000297256400049
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMorphine
dc.subjectAngiogenesis
dc.subjectTc-99m Tetrofosmin
dc.subjectMicrovessel density
dc.subjectDoppler sonography
dc.titleEvaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC
dc.typeArticle

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