The effect of hesperetin on ischemia-reperfusion injury in rat ovary

Basit Öğe Kaydı
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.contributor.authorGungor, Ayse Nur Cakir
dc.contributor.authorGencer, Meryem
dc.contributor.authorKaraca, Turan
dc.contributor.authorHacivelioglu, Servet
dc.contributor.authorUysal, Ahmet
dc.contributor.authorKorkmaz, Fatma
dc.contributor.authorDemirtas, Selim
dc.date.accessioned2025-01-27T20:35:09Z
dc.date.available2025-01-27T20:35:09Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHesperidin (HES), a citrus fruit extract, has beneficial effects on various ischemia/reperfusion (I/R) models. We aimed to evaluate the possible positive effects of hesperetin (HPT), an active metabolite of HES, on a rat ovarian I/R model. We divided 24 Wistar Albino rats into four groups. Group I (n = 6) was sham operated, Group II (n = 6) was the I/R group, Group III (n = 6) was the I/R + solvent group and Group IV (n = 6) was the I/R + HPT group. Three hours of ischemia and 3 h of reperfusion were performed on each rat in Groups II, III, and IV. Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III. Group, and 50 mg/kg of HPT dissolved in DMSO was given intraperitoneally to the rats in the IV. Group 30 min before reperfusion. After 3 h of reperfusion, the ipsilateral ovaries of the rats were examined immunohistochemically to detect apoptosis. Hematoxylin and eosin (H and E) staining demonstrated less edema and hemorrhage in the group where HPT was applied. Caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining showed significantly lower apoptosis in the group where HPT was used when compared to either the I/R or solvent group. To the best of our knowledge, this is the first study that shows the beneficial effects of HPT in an ovarian I/R injury. HPT improved tissue damage and apoptosis caused by I/R injury. To identify the possible positive effects of HPT in ovarian torsion of humans and use in clinical practice, more studies must be performed.
dc.identifier.doi10.1007/s00404-014-3267-8
dc.identifier.endpage769
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue4
dc.identifier.pmid24806622
dc.identifier.scopus2-s2.0-84921959578
dc.identifier.scopusqualityQ2
dc.identifier.startpage763
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3267-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23584
dc.identifier.volume290
dc.identifier.wosWOS:000341826700030
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectCaspase 3
dc.subjectFlavonones
dc.subjectHesperidin
dc.subjectTUNEL
dc.subjectOvarian torsion
dc.subjectIschemia/reperfusion injury
dc.titleThe effect of hesperetin on ischemia-reperfusion injury in rat ovary
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu