Biocompatible poly(galacturonic acid) micro/nanogels with controllable degradation via tunable chemical crosslinking

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dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorAri, Betül
dc.contributor.authorSutekin, S. Duygu
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:58:02Z
dc.date.available2025-01-27T20:58:02Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHere, one-pot labor-less preparation of two different polygalacturonic acid (PGA) micro/nanogel formulations, PGA-1 and PGA-2, by respectively crosslinking the PGA chains with divinyl sulfone (DVS) and trimethylolpmpane triglycidyl ether (TMPGDE) were reported. Various crosslinker ratios, 2.5, 10, 50, and 100% were used for both crosslinkers to demonstrate the tunability of their degradation properties. The PGA micro/nanogels were found spherical-shaped porous particles in 0.5-5.0 mu m size range by SEM. The hydrolytic degradation and stability of PGA micro/nanogels in pH 1.0, 7.4, and 9.0 buffer solutions can be controlled by changing the degree of crosslinking. Accordingly, 32 +/- 8% and 36 +/- 2% weight losses were attained for PGA-1-10% and PGA-2-10% micro/nanogels at pH 1, respectively, and 46 +/- 6%, and 68 +/- 6% degradations were determined at pH 7.4 within 4 weeks. However, no degradation was observed for both PGA-based micro/nanogel formulations prepared at 25% and 100% crosslinker ratios at all pH conditions. All PGA-based micro/nanogels were totally degraded within 7-10 days at pH 9.0. In the presence of pectinase and amyloglucosidase enzymes, all formulations of PGA micro/nanogels showed more than 80% degradation within 12 h. Furthermore, both PGA formulations showed no significant cytotoxicity against L929 fibroblast cells with 90% and above cell viability up to 250 mg/mL concentrations.
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University [FBA2020-3248]
dc.description.sponsorshipThis research was supported by the Scientific Research Commission of Canakkale Onsekiz Mart University with the project numbered FBA2020-3248. Therefore, we would like to thank the aforementioned institution.
dc.identifier.doi10.1016/j.ijbiomac.2021.12.107
dc.identifier.endpage363
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid34998881
dc.identifier.scopus2-s2.0-85122782674
dc.identifier.scopusqualityQ1
dc.identifier.startpage351
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.12.107
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26586
dc.identifier.volume201
dc.identifier.wosWOS:000821287200005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPolygalacturonic acid
dc.subjectBiodegradable microgels
dc.subjectPorous biocompatible materials
dc.titleBiocompatible poly(galacturonic acid) micro/nanogels with controllable degradation via tunable chemical crosslinking
dc.typeArticle

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