The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

Basit Öğe Kaydı
dc.authoridkaragoz, mehmet ali/0000-0002-0144-2041
dc.contributor.authorKaragoz, Mehmet Ali
dc.contributor.authorDoluoglu, Omer Gokhan
dc.contributor.authorUnverdi, Hatice
dc.contributor.authorResorlu, Berkan
dc.contributor.authorSunay, Mehmet Melih
dc.contributor.authorDemirbas, Arif
dc.contributor.authorKarakan, Tolga
dc.date.accessioned2025-01-27T21:01:45Z
dc.date.available2025-01-27T21:01:45Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats. Materials and Methods: A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham operated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS). Results: JTBS was determined as 8.8 +/- 2.7 in the Sham group, 5.08 +/- 1.9 in the T/D+papaverine group, 5.29 +/- 2.3 in the T/D +alprostadil group and 2.86 +/- 1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43 We) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14 %) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4. Conclusion: The present study indicated that spermatic cord administration of alprostadil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular ischemia reperfusion injury.
dc.identifier.doi10.1590/s1677-5538.ibju.2017.0600
dc.identifier.endpage622
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue3
dc.identifier.pmid29617080
dc.identifier.scopus2-s2.0-85049001551
dc.identifier.scopusqualityQ2
dc.identifier.startpage617
dc.identifier.urihttps://doi.org/10.1590/s1677-5538.ibju.2017.0600
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27177
dc.identifier.volume44
dc.identifier.wosWOS:000432787900027
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPapaverine
dc.subjectAlprostadil
dc.subjectSpermatic Cord Torsion
dc.titleThe protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu