The effect of varicocoelectomy on the relationship of oxidative stress in peripheral and internal spermatic vein with semen parameters

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dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridCOLAK, Cemil/0000-0001-5406-098X
dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.authoridCAMTOSUN, AHMET/0000-0002-5390-9088
dc.authoridEdiz, Caner/0000-0001-9717-1209
dc.contributor.authorAltintas, R.
dc.contributor.authorEdiz, C.
dc.contributor.authorCelik, H.
dc.contributor.authorCamtosun, A.
dc.contributor.authorTasdemir, C.
dc.contributor.authorTanbek, K.
dc.contributor.authorTekin, S.
dc.date.accessioned2025-01-27T21:02:17Z
dc.date.available2025-01-27T21:02:17Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this prospective controlled study was to investigate the levels of reactive oxygen species (ROS), including asymmetric dimethylarginine (ADMA), oxidative stress index (OSI) and total oxidant capacity (TOC), and antioxidants with total antioxidant capacity (TAC) in peripheral and internal spermatic veins blood, the relationship of these factors with sperm parameters in the infertile varicocoele patients, and the amelioration effect of varicocoelectomy on these outcomes. Thirty-one primary infertile varicocoele patients and 31 fertile control patients evaluated for determining the levels of ADMA, TOC, OSI, superoxide dismutase (SOD), glutathione (GSH), TAC, and semen analysis. The patients' preoperative SOD, GSH and TAC levels, which were significantly lower than the controls, significantly increased postoperatively. Although SOD and GSH were significantly higher in spermatic vein compared to median cubital vein, TAC was significantly higher in median cubital vein. ADMA, TOC and OSI were significantly higher in the patient group. TOC and OSI were significantly higher in spermatic vein compared to median cubital vein. Postoperative TOC, OSI and ADMA reduced to the control levels. Total antioxidant capacity in the peripheral circulation and oxidative stress index in the internal spermatic vein could give an idea about the possible improvement in sperm count acquired by varicocoelectomy.
dc.identifier.doi10.1111/andr.12172
dc.identifier.endpage446
dc.identifier.issn2047-2919
dc.identifier.issn2047-2927
dc.identifier.issue3
dc.identifier.pmid26945912
dc.identifier.scopus2-s2.0-84959572911
dc.identifier.scopusqualityQ1
dc.identifier.startpage442
dc.identifier.urihttps://doi.org/10.1111/andr.12172
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27325
dc.identifier.volume4
dc.identifier.wosWOS:000375881200011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectasymmetric dimethylarginine
dc.subjectoxidative stress index
dc.subjecttotal antioxidant capacity
dc.subjecttotal oxidant capacity
dc.subjectvaricocoele
dc.titleThe effect of varicocoelectomy on the relationship of oxidative stress in peripheral and internal spermatic vein with semen parameters
dc.typeArticle

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