Recent Advances of Silver Nanoparticles in Wound Healing: Evaluation of In Vivo and In Vitro Studies

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dc.authorid0009-0002-5260-6111
dc.authorid0000-0002-2913-2846
dc.authorid0009-0009-5996-6567
dc.authorid0000-0003-4056-1673
dc.contributor.authorKaya, Melis
dc.contributor.authorAkdasci, Emir
dc.contributor.authorEker, Furkan
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:59Z
dc.date.available2026-02-03T11:59:59Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSilver nanoparticles (AgNPs) have attracted significant attention in recent years in diverse fields owing to their broad mechanisms of action. In particular, the wound healing process has become one of the main fields where the therapeutic potential of AgNPs is highlighted. AgNPs can be used as monotherapy or incorporated into composite structures in various formulations such as nanogels, hydrogels, powders, ointments, and sprays, for the treatment of a wide range of wound types including burns, excisional and incisional wounds, bone defects, surgical wounds, and diabetic ulcers. This widespread use is attributed to the strong antibacterial, anti-inflammatory, antioxidant, and cell proliferation-promoting biological properties of AgNPs. Moreover, AgNPs exhibit synergistic effects when combined with conventional antibiotics, enhancing their efficiency against resistant bacterial strains or even restoring the lost antibacterial activity. These biological properties enable AgNPs to reduce infection risk while simultaneously promoting high-quality healing by accelerating tissue regeneration. The therapeutic effectiveness of AgNPs is influenced by their physicochemical properties, including particle size, shape, and surface chemistry. In particular, synthesis methods play a significant role in determining both the biological activity and the safety profile of AgNPs. Among various methods, green synthesis approaches stand out for enabling the production of environmentally friendly, non-toxic, and highly biocompatible AgNPs. In this review, the mechanisms of action of AgNPs in wound healing are examined in detail, and recent scientific developments in this field are evaluated based on current in vitro, in vivo, and clinical studies.
dc.identifier.doi10.3390/ijms26209889
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue20
dc.identifier.pmid41155186
dc.identifier.scopus2-s2.0-105020241014
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms26209889
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34455
dc.identifier.volume26
dc.identifier.wosWOS:001601722100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectsilver nanoparticles
dc.subjectantibacterial activity
dc.subjectanti-inflammatory properties
dc.subjectantioxidant activity
dc.subjecttissue regeneration
dc.subjectwound healing
dc.subjectbiomedical applications
dc.subjecttoxicity
dc.titleRecent Advances of Silver Nanoparticles in Wound Healing: Evaluation of In Vivo and In Vitro Studies
dc.typeReview

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