The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorIsik, Selda
dc.contributor.authorKilic, Sevilay
dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorTurkon, Hakan
dc.contributor.authorCevizci, Sibel
dc.contributor.authorHiz, Meliha Merve
dc.date.accessioned2025-01-27T20:44:21Z
dc.date.available2025-01-27T20:44:21Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis. Aim: To investigate the correlation between the psoriasis area severity index (PASO, IMA and MPV levels in patients with psoriasis. Material and methods: This cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Canakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups. Results: The mean IMA values were 0.85 +/- 0.15 and 0.79 +/- 0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 +/- 1.14 and 9.19 +/- 1.28 in the psoriasis patients and control groups, respectively) (p = 0.435). Conclusions: Ischemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.
dc.identifier.doi10.5114/ada.2016.61606
dc.identifier.endpage293
dc.identifier.issn1642-395X
dc.identifier.issue4
dc.identifier.pmid27605901
dc.identifier.scopus2-s2.0-84983425986
dc.identifier.scopusqualityQ2
dc.identifier.startpage290
dc.identifier.urihttps://doi.org/10.5114/ada.2016.61606
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24546
dc.identifier.volume33
dc.identifier.wosWOS:000382410900009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectpsoriasis
dc.subjectischemia-modified albumin
dc.subjectmean platelet volume
dc.subjectpsoriasis area severity index
dc.titleThe correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis
dc.typeArticle

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