Association between serum inhibin-B levels and coronary artery disease in aging males

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dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.authoridCOSANSU, KAHRAMAN/0000-0002-4063-5874
dc.contributor.authorKocoglu, Hasan
dc.contributor.authorAlan, Cabir
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorMalkoc, Ercan
dc.contributor.authorCosansu, Kahraman
dc.contributor.authorKinlmaz, Bahadir
dc.contributor.authorErtung, Yunus
dc.date.accessioned2025-01-27T20:29:11Z
dc.date.available2025-01-27T20:29:11Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Atherosclerosis is a systemic disorder. It is a frequent leading cause of coronary artery disease (CAD). Similarly, atherosclerotic vascular alterations could lead to testicular arterial blood flow reduction and impairment of testicular function with age. Inhibin-B has been validated as a valuable serum marker of testicular functions and its correlation with testicular volume was shown in some studies done before. The purpose of this study is to investigate the association between serum inhibin-B levels and CAD in elderly men. Material and methods: Between March 2009 and March 2010, fifty-two 50-80-year-old consecutive patients with Gensini score over 20 and ejection fraction (EF) > 50% were included in the study as the CAD group. Fifty healthy men without any cardiac disease history were recruited as the control group. All patients in the CAD group who had indications for coronary artery angiography underwent selective coronary artery angiography. Results: Inhibin-B, total testosterone and testicular volume levels were found to be significantly lower in the CAD group in comparison with the control group (p = 0.004, p < 0.0001, and p = 0.001 respectively). Conclusions: In this study, although no correlation was found in CAD patients between Gensini score and inhibin-B or testicular volume, inhibin-B levels and testicular volume were significantly lower in patients with CAD than in healthy men. In order to fully assess the relationship between serum inhibin-B levels and CAD, multi-centered prospective and longitudinal studies must be done in elderly male patients.
dc.identifier.doi10.5114/aoms.2013.34410
dc.identifier.endpage801
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue5
dc.identifier.pmid24273559
dc.identifier.scopus2-s2.0-84888117144
dc.identifier.scopusqualityQ1
dc.identifier.startpage796
dc.identifier.urihttps://doi.org/10.5114/aoms.2013.34410
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22856
dc.identifier.volume9
dc.identifier.wosWOS:000326990200004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectinhibin-B
dc.subjectcoronary artery disease
dc.titleAssociation between serum inhibin-B levels and coronary artery disease in aging males
dc.typeArticle

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