Electrocatalytic oxidation of moxifloxacin hydrochloride on modified glassy carbon surface and determination in Avelox tablets
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bulgarian Academy of Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This work presents an electroanalytical method for the determination of moxifloxacin hydrochloride (MOX) in tablets. The surface of the glassy carbon electrode (GCE) was modified by electrochemical polymerization of 4-aminobenzene sulfonic acid in phosphate buffer solution (pH 7.0).The oxidative behavior of MOX was studied at glassy carbon and modified glassy carbon electrodes in different buffer systems using the cyclic voltammetry technique. The modified glassy carbon electrode (poly(4-ABSA/GCE) has very high catalytic ability for electrooxidation of MOX. Acetate buffer (pH 5.0) was selected as the optimum medium for the oxidation of MOX at poly(4-ABSA/GCE) due to the highest electronic signal increase obtained. Differential pulse voltammetry (DPV) and chronoamperometry (CA) techniques were used for voltammetric determination of MOX. The values of limit of detection (LOD) and limit of quantification (LOQ) were determined to be 3.19×10 -7 M and 1.06×10 -6 M for DPV; and 5.50×10 -7 M and 1.83×10 -6 M for CA, respectively. A highly sensitive electroanalytical method for the determination of MOX in Avelox tablets by DPV was described. © 2019 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria
Açıklama
Anahtar Kelimeler
4-Aminobenzene sulfonic acid; Electrocatalytic ability; Electropolymerization; Modified glassy carbon electrode; Moxifloxacin hydrochloride; Voltammetry
Kaynak
Bulgarian Chemical Communications
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
51
Sayı
1
