Different patterns of manic/hypomanic symptoms in depression: A pilot modification of the hypomania checklist-32 to assess mixed depression

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dc.authoridYoungstrom, Eric Arden/0000-0003-2251-6860
dc.authoridOZERDEM, AYSEGUL/0000-0002-9455-5896
dc.authoridyalin, nefize/0000-0003-4298-5074
dc.authoridAydemir, Omer/0000-0003-3050-1263
dc.contributor.authorPrieto, Miguel L.
dc.contributor.authorYoungstrom, Eric A.
dc.contributor.authorOzerdem, Aysegul
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorQuiroz, Danilo
dc.contributor.authorAydemir, Omer
dc.contributor.authorYalin, Nefize
dc.date.accessioned2025-01-27T21:01:40Z
dc.date.available2025-01-27T21:01:40Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: There are no self-report scales that assess manic/hypomanic symptoms in patients with depression. The aim of this study was to explore the use of a modified screening instrument for bipolar disorder to assess current manic/hypomanic symptoms in patients with a depressive episode. Methods: The study sample consisted of 188 patients with Structured Clinical Interview for DSM-IV-TR disorders (SCID) confirmed bipolar or major depressive disorder. We modified the Hypomania Checklist-32 (mHCL-32) to assess current instead of lifetime symptoms. An Exploratory Factor Analysis (EFA) was conducted to identify clusters of mHCL-32 items that were endorsed concurrently. A Latent Class Analysis (LCA) was carried out to identify groups of patients with similar mHCL-32 item endorsement patterns. Results: The EPA identified 3 factors: factor #1 (elation-disinhibition-increased goal directed activity), factor #2 (risk-taking-impulsivity-substance use) and factor #3 (distractibility-irritability). The LCA yielded 3 classes (2 showing manic/hypomanic features). While class #1 patients endorsed more items related to disinhibition and racing thoughts, class #2 patients recognized more items associated with irritability and substance use Limitations: Lack of an adequate gold standard measure of mixed depression to compare to, the cross-sectional design and the lack of a validation sample. Conclusions: The mHCL-32 scale allowed a comprehensive and convergent delineation of hypomanic/manic symptoms in depression. Further validation of these findings is needed. (C) 2014 Elsevier B.V. All rights reserved,
dc.description.sponsorshipMayo Foundation
dc.description.sponsorshipMayo Foundation.
dc.identifier.doi10.1016/j.jad.2014.09.047
dc.identifier.endpage360
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid25451437
dc.identifier.scopus2-s2.0-84913590922
dc.identifier.scopusqualityQ1
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1016/j.jad.2014.09.047
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27141
dc.identifier.volume172
dc.identifier.wosWOS:000346643000050
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBipolar disorder
dc.subjectmHCL-32 scale
dc.subjectMixed depression
dc.subjectManic/hypomanic
dc.titleDifferent patterns of manic/hypomanic symptoms in depression: A pilot modification of the hypomania checklist-32 to assess mixed depression
dc.typeArticle

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