Neutrophil to lymphocyte ratio may be a predictive marker of poor prognosis in Legg-Calve-Perthes disease

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dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.authoridBuyukdogan, Kadir/0000-0001-9540-5809
dc.contributor.authorKaymaz, Burak
dc.contributor.authorBuyukdogan, Kadir
dc.contributor.authorKaymaz, Nazan
dc.contributor.authorKomorcu, Erkam
dc.contributor.authorGolge, Umut Hatay
dc.contributor.authorGoksel, Ferdi
dc.contributor.authorAksoy, Mehmet Cemalettin
dc.date.accessioned2025-01-27T20:52:29Z
dc.date.available2025-01-27T20:52:29Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLegg-Calve-Perthes disease (LCPD) is the idiopathic avascular necrosis of the femoral head in childhood. The pathologic changes seen in the femoral head are likely a result of vascular factors. Blood neutrophil to lymphocyte (N/L) ratio is a simple marker of subclinical inflammation. This study aims to to analyse the predictive ability of N/L ratio for the prognosis in LCPD patients. Methods: Patients who had been diagnosed as LCPD from 2008 to 2014 were investigated retrospectively and 40 LCPD patients (33 male and 7 female) and 25 healthy age and sex-matched children (controls) were included in the study. LCPD patients were divided into 2 groups according to expected prognosis (good prognosis expected Herring A and B patients as Group I and poor prognosis expected Herring B-C and C patients as Group II) and healthy children (control) were included in Group III. All the patients' hematological markers were analysed. Results: Mean age was 7.1 +/- 2.0 years in group I (4.9-12 years), 8.3 +/- 2.2 years (4-12.5 years) in group II and 7.8 +/- 1.3 years (6-12 years) in group III. Mean values for Groups I, II and III for neutrophil to lymphocyte (N/L) ratio were 1.13 +/- 0.65, 1.75 +/- 0.95, 1.08 +/- 0.37, respectively. The mean neutrophil to lymphocyte (N/L) ratio of Group II was higher than the other 2 groups (p = 0.003). Conclusions: N/L ratio may give us information about the natural course of LCPD and may be used as independent predictor of prognosis in patients with LCPD.
dc.identifier.doi10.5301/hipint.5000381
dc.identifier.endpage601
dc.identifier.issn1120-7000
dc.identifier.issn1724-6067
dc.identifier.issue6
dc.identifier.pmid27229163
dc.identifier.scopus2-s2.0-85000366338
dc.identifier.scopusqualityQ1
dc.identifier.startpage598
dc.identifier.urihttps://doi.org/10.5301/hipint.5000381
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25776
dc.identifier.volume26
dc.identifier.wosWOS:000388504400018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofHip International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNeutrophil to lymphocyte ratio
dc.subjectPerthes
dc.subjectPrognosis
dc.titleNeutrophil to lymphocyte ratio may be a predictive marker of poor prognosis in Legg-Calve-Perthes disease
dc.typeArticle

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