Association between apparent diffusion coefficient and intervertebral disc degeneration in patients with ankylosing spondylitis

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorResorlu, Mustafa
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorResorlu, Hatice
dc.contributor.authorAdam, Gurhan
dc.contributor.authorAkbal, Ayla
dc.contributor.authorCevizci, Sibel
dc.contributor.authorSariyildirim, Abdullah
dc.date.accessioned2025-01-27T20:44:02Z
dc.date.available2025-01-27T20:44:02Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To assess the relation between ankylosing spondylitis (AS) and degenerative disc disease emerging in association with various intrinsic and extrinsic factors and to evaluate the correlation between degree of degeneration in intervertebral discs and apparent diffusion coefficient (ADC) values. Methods: Thirty-five patients with AS and a control group of 35 patients were included in the study. Three hundred fifty intervertebral discs were assessed in terms of degeneration by analyzing signal intensities and morphologies on T2 weighted series of a 1.5 Tesla magnetic resonance scanner. ADC values were determined in diffusion weighted images (DWI) using a b value of 500 s/mm(2). Patients in the AS and control groups were compared in terms of intervertebral disc degeneration, and association between degree of degeneration and ADC values was analyzed. Results: The mean of total degeneration degrees for five lumbar intervertebral discs was significantly higher in the patients with AS compared to the control group (16.77 +/- 4.67 vs 13.00 +/- 4.08, respectively; P=0.001). When intervertebral discs were analyzed separately, disc degeneration was again significantly higher in patients with AS compared to the control group, with the exception of L5-S1. Age, cholesterol level, triglyceride level, duration of disease and BASFI index were significantly associated with degree of degeneration in patients with AS. A negative correlation was determined between disc degeneration and ADC value. Conclusion: AS is a risk factor for degenerative disc disease due to its systemic effects, the fact it leads to posture impairment and its inflammatory effects on the vertebrae. A decrease in ADC values is observed as degeneration worsens in degenerative disc disease.
dc.identifier.endpage1246
dc.identifier.issn1940-5901
dc.identifier.issue1
dc.identifier.pmid25785119
dc.identifier.scopus2-s2.0-84922971925
dc.identifier.scopusqualityN/A
dc.identifier.startpage1241
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24458
dc.identifier.volume8
dc.identifier.wosWOS:000349897200152
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnkylosing spondylitis
dc.subjectapparent diffusion coefficient
dc.subjectintervertebral disc degeneration
dc.subjectmagnetic resonance imaging
dc.titleAssociation between apparent diffusion coefficient and intervertebral disc degeneration in patients with ankylosing spondylitis
dc.typeArticle

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