Neuroprotective Effect of Humic Acid on Focal Cerebral Ischemia Injury: an Experimental Study in Rats

Basit Öğe Kaydı
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorOzkan, Adile
dc.contributor.authorSen, Halil Murat
dc.contributor.authorSehitoglu, Ibrahim
dc.contributor.authorAlacam, Hasan
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.date.accessioned2025-01-27T21:01:28Z
dc.date.available2025-01-27T21:01:28Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractStroke is still a major cause of death and permanent neurological disability. As humic acids are well-known antioxidant molecules, the purpose of this study was to investigate the potential neuroprotective effects of humic acid in a focal cerebral ischemia model. Twenty-four rats were divided equally into three groups. A middle cerebral artery occlusion model was performed in this study where control (group II) and humic acid (group III) were administered intraperitoneally following an ischemic experimental procedure. Group I was evaluated as sham. Malondialdehyde (MDA), superoxide dismutase (SOD), and nuclear respiratory factor-1 (NRF-1) levels were analyzed biochemically on the right side of the ischemic cerebral hemisphere, while ischemic histopathological studies were completed on the left side to investigate the antioxidant status. Biochemical results showed that SOD and NRF-1 levels were significantly increased in the humic acid group (III) compared with the control group (II) while MDA levels were significantly decreased. On histopathological examination, cerebral edema, vacuolization, degeneration, and destruction of neural elements were decreased in the humic acid group (III) compared with the control group (II). Cerebral ischemia was attenuated by humic acid administration. These observations indicate that humic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress.
dc.identifier.doi10.1007/s10753-014-0005-0
dc.identifier.endpage39
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1
dc.identifier.pmid25173888
dc.identifier.scopus2-s2.0-85027945954
dc.identifier.scopusqualityQ1
dc.identifier.startpage32
dc.identifier.urihttps://doi.org/10.1007/s10753-014-0005-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27045
dc.identifier.volume38
dc.identifier.wosWOS:000349015900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcerebrum
dc.subjecthumic acid
dc.subjectischemia
dc.titleNeuroprotective Effect of Humic Acid on Focal Cerebral Ischemia Injury: an Experimental Study in Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu