Serum glycoprotein 96, a heat shock protein 90 paralog, as a potential biomarker in psoriasis: a prospective case-control study

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dc.contributor.authorKaya, Ozge
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorMermutlu, Selda Isik
dc.contributor.authorKilic, Sevilay Oguz
dc.contributor.authorKaya, Hakki
dc.date.accessioned2026-02-03T12:03:05Z
dc.date.available2026-02-03T12:03:05Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPsoriasis is a chronic, immune-mediated skin disease characterized by keratinocyte stress and cytokine-driven inflammation. Glycoprotein 96 (gp-96), a heat shock protein 90 paralog located in the endoplasmic reticulum, plays a critical role in the folding of Toll-like receptors and may contribute to the amplification of inflammatory responses. This study investigated serum gp-96 levels in patients with psoriasis compared to healthy controls and explored potential associations with clinical features. A total of 44 psoriasis patients and 44 healthy individuals were enrolled in a prospective case-control study. Serum gp-96 concentrations were quantified using ELISA. Patients' demographic and clinical data, including PASI scores, nail and joint involvement, and treatment modalities, were collected. Serum gp-96 levels were significantly higher in psoriasis patients than in healthy controls (median 15.92 vs. 9.33 ng/mL, p < 0.001). However, gp-96 levels did not correlate significantly with PASI score, age, disease duration, or other clinical variables. ROC analysis revealed that serum gp-96 has good diagnostic performance in distinguishing psoriasis patients from controls, with an AUC of 0.83 and an optimal cut-off value of 11.57 ng/mL (sensitivity and specificity: 77.3%). A borderline association with nail involvement was observed, suggesting a potential link between gp-96 levels and localized keratinocyte stress. These findings suggest that gp-96 may be a promising diagnostic biomarker in psoriasis, independent of disease severity, and could play a role in the pathogenesis of the disease through its involvement in ER stress and innate immune activation. Further studies with larger cohorts and tissue-level investigations are warranted to validate these results and explore the therapeutic potential of targeting gp-96 in psoriatic disease.
dc.description.sponsorshipanakkale Onsekiz Mart University Scientific Research Projects Unit [TSA 2022-3858]
dc.description.sponsorshipThis study was supported financially by the Canakkale Onsekiz Mart University Scientific Research Projects Unit as an independent research project (project number: TSA 2022-3858).
dc.identifier.doi10.1007/s00403-025-04492-5
dc.identifier.issn0340-3696
dc.identifier.issn1432-069X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105026409347
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00403-025-04492-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34969
dc.identifier.volume318
dc.identifier.wosWOS:001653243900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofArchives of Dermatological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectPsoriasis
dc.subjectGlycoprotein 96
dc.subjectHeat shock protein 90
dc.subjectEndoplasmic reticulum
dc.titleSerum glycoprotein 96, a heat shock protein 90 paralog, as a potential biomarker in psoriasis: a prospective case-control study
dc.typeArticle

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