The Role of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Pathogenesis of Ulcerative Colitis and Crohn's Disease

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dc.authoridDemirci, Mehmet/0000-0001-9670-2426
dc.authoridkurt, enes ali/0000-0001-8056-4428
dc.contributor.authorKurt, Enes A.
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorOzbey, Dogukan
dc.contributor.authorGareayaghi, Nesrin
dc.contributor.authorEskazan, Tugce
dc.contributor.authorErzin, Yusuf Z.
dc.contributor.authorCakan, Huseyin
dc.date.accessioned2025-01-27T20:39:19Z
dc.date.available2025-01-27T20:39:19Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases with uncertain etiology. We aimed to determine the amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in the intestinal microbiota of these patients and to correlate their amounts with blood IL-8, IL-10, and IL-12 cytokine levels. Methods: Thirty UC, 30 CDs, and 46 healthy controls were included. IL-8, IL-10, and IL-12 levels of blood samples were analyzed by ELISA. The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii were determined by the LightCycler 480 qPCR system. Results: F. prausnitzii, A. muciniphila, IL-10, and IL-12 decreased in patient groups, while IL-8 decreased in UC but increased in CD. A significant difference was detected between the patient and control groups in terms of F. prausnitzii, A. muciniphila, and IL-8, but not for others. The amount of F. prausnitzii was correlated with IL-8 and IL-10 in UC and with IL-10 in CD patients. Conclusions: The decrease in the amount of F. prausnitzii was associated with the increase in UC disease severity. A. muciniphila and F. prausnitzii were detected in lower amounts in both diseases. F. prausnitzii decreased more with the severity of UC, suggesting that these bacteria may have complex roles in their etiopathogenesis.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpascedil;a [33704]
dc.description.sponsorshipSource of Funds: This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University-Cer- rahpa & scedil;a. Project number: 33704.
dc.identifier.doi10.7754/Clin.Lab.2023.230711
dc.identifier.endpage166
dc.identifier.issn1433-6510
dc.identifier.issue1
dc.identifier.pmid38213219
dc.identifier.scopus2-s2.0-85182098936
dc.identifier.scopusqualityQ3
dc.identifier.startpage157
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2023.230711
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23920
dc.identifier.volume70
dc.identifier.wosWOS:001178807900020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectUlcerative Colitis
dc.subjectCrohn's Disease
dc.subjectgut microbiota
dc.subjectAkkermansia muciniphila
dc.subjectFaecalibacterium prausnitzii
dc.titleThe Role of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Pathogenesis of Ulcerative Colitis and Crohn's Disease
dc.typeArticle

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