Rhythms of serum melatonin in rats with acute spinal cord injury at the cervical and thoracic regions

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dc.authoridGunduz, Bulent/0000-0003-0497-8287
dc.contributor.authorGezici, A. R.
dc.contributor.authorKarakas, A.
dc.contributor.authorErgun, R.
dc.contributor.authorGunduz, B.
dc.date.accessioned2025-01-27T20:23:01Z
dc.date.available2025-01-27T20:23:01Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To evaluate the serum melatonin levels in acute period of the spinal cord injury (SCI) caused by trauma in the rats. Background: Traumatic SCI induces many types of physiological and pathological damage, including hormonal level variations. Methods: Forty male Sprague-Dawley rats were divided randomly into four groups. In the control group, neither laminectomy nor SCI were performed; only a large laminectomy was performed without SCI in the sham group. In the cervical and thoracic spinal trauma groups, laminectomies at C5-6 and a T6-7 were performed, respectively, followed by clip compression of the spinal cord. Blood samples were drawn 2, 6, 12 and 24 h after the procedures and assayed immediately. Results: The levels of melatonin in the neurotrauma groups were high in the first 2 h, but at the end of sixth hour, melatonin levels increased in sham-operated group, decreased in neurotrauma groups and did not change in control group. At the 12th hour, melatonin levels continued to decrease in thoracic group significantly. At the 24th hour, the melatonin levels decreased in the cervical, control and sham groups, whereas melatonin levels increased in the thoracic group. Conclusions: The present study revealed that (1) activation of endogen melatonin secretion of the organism starts immediately after the SCI, but it shows a great lowering trend between 2 and 6h post-SCI, (2) the tetraplegic rats, which had complete injuries at the lower cervical spinal cord, could not produce enough melatonin secretion; on the contrary, the paraplegic rats, which had complete injury at the upper thoracic spinal cord, showed normal melatonin secretion. Spinal Cord (2010) 48, 10-14; doi:10.1038/sc.2009.73; published online 23 June 2009
dc.identifier.doi10.1038/sc.2009.73
dc.identifier.endpage14
dc.identifier.issn1362-4393
dc.identifier.issue1
dc.identifier.pmid19546875
dc.identifier.scopus2-s2.0-75149120613
dc.identifier.scopusqualityQ1
dc.identifier.startpage10
dc.identifier.urihttps://doi.org/10.1038/sc.2009.73
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22096
dc.identifier.volume48
dc.identifier.wosWOS:000273349400003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofSpinal Cord
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectmelatonin
dc.subjectneuroprotection
dc.subjectspinal cord injury
dc.titleRhythms of serum melatonin in rats with acute spinal cord injury at the cervical and thoracic regions
dc.typeArticle

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