Influence of Artemisia annua (Asteraceae) leaf extract on immunity in Galleria mellonella (Lepidoptera: Pyralidae)

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dc.authoridKAYA, Serhat/0000-0002-0984-2824
dc.contributor.authorOzturk, Rahile
dc.contributor.authorKaya, Serhat
dc.date.accessioned2025-01-27T20:39:04Z
dc.date.available2025-01-27T20:39:04Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSweet sagewort (Artemisia annua) is a species that has been used for many years to treat high fever due to its artemycin content. Artemycin is the active ingredient in antimalarial drugs. Additionally, the plant's leaves are consumed as tea or aqueous extract. Invertebrate model organism Galleria mellonella is preferred in immune studies due to its ease of administration, natural immunity shared with mammals, including humans, and rapid determination of results. In this research, we systematically assessed the impact of A. annua extract on the immune system of animals by employing the G. mellonella model organism. We meticulously examined key facets of innate immune responses, including total hemocyte count, encapsulation-melanization, and phenoloxidase activity. Furthermore, we delved into the effects on antioxidant enzyme activity, specifically superoxide dismutase, catalase, and lipid peroxidase. The hemocyte count showed a statistically significant decrease across all given doses of the A. annua extract when compared to the control groups. The A. annua extract had no effect on the catalase activity, malondialdehyde amount, phenoloxidase activity, or melanization response of G. mellonella larvae, according to the findings of our study. Nonetheless, it enhanced SOD activity. In comparison to the control groups, it decreased the strong encapsulation response, which is a cell-mediated immune response, at all doses. While the A. annua extract had little effect on enzymatic processes in animals, it reduced cell-mediated immune responses by altering cell behaviours and count with cytotoxic and genotoxic effects.
dc.description.sponsorshipSelcuk University BAP Coordinatorship [21401018]
dc.description.sponsorshipWe would like to thank Selcuk University BAP Coordinatorship for supporting our work with the project numbered 21401018. We also thank COMUEDAM officials for allowing us to use the laboratory facilities.
dc.identifier.doi10.1007/s11756-024-01677-7
dc.identifier.endpage1840
dc.identifier.issn0006-3088
dc.identifier.issn1336-9563
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85192164464
dc.identifier.scopusqualityQ2
dc.identifier.startpage1827
dc.identifier.urihttps://doi.org/10.1007/s11756-024-01677-7
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23852
dc.identifier.volume79
dc.identifier.wosWOS:001214870200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBiologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectArtemisia annua
dc.subjectCatalase
dc.subjectEncapsulation- melanization
dc.subjectGalleria mellonella
dc.subjectLipid peroxidase
dc.subjectPhenoloxidase
dc.subjectSuperoxide dismutase
dc.subjectTotal hemocyte count
dc.titleInfluence of Artemisia annua (Asteraceae) leaf extract on immunity in Galleria mellonella (Lepidoptera: Pyralidae)
dc.typeArticle

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