Plant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review

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dc.authoridKoch, Wojciech/0000-0001-8749-9657
dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.authoridWawruszak, Anna/0000-0003-2388-4577
dc.authoridMichalak-Tomczyk, Magdalena/0000-0002-2244-4118
dc.contributor.authorKoch, Wojciech
dc.contributor.authorZagorska, Justyna
dc.contributor.authorMichalak-Tomczyk, Magdalena
dc.contributor.authorKarav, Sercan
dc.contributor.authorWawruszak, Anna
dc.date.accessioned2025-01-27T20:11:55Z
dc.date.available2025-01-27T20:11:55Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPlants are a rich source of secondary metabolites, among which phenolics are the most abundant. To date, over 8000 various polyphenolic compounds have been identified in plant species, among which phenolic acids, flavonoids, coumarins, stilbenes and lignans are the most important ones. Acne is one of the most commonly treated dermatological diseases, among which acne vulgaris and rosacea are the most frequently diagnosed. In the scientific literature, there is a lack of a detailed scientific presentation and discussion on the importance of plant phenolics in the treatment of the most common specific skin diseases, e.g., acne. Therefore, the aim of this review is to gather, present and discuss the current state of knowledge on the activity of various plant phenolics towards the prevention and treatment of acne, including in vitro, in vivo and human studies. It was revealed that because of their significant antibacterial, anti-inflammatory and antioxidant activities, phenolic compounds may be used in the treatment of various types of acne, individually as well as in combination with commonly used drugs like clindamycin and benzoyl peroxide. Among the various phenolics that have been tested, EGCG, quercetin and nobiletin seem to be the most promising ones; however, more studies, especially clinical trials, are needed to fully evaluate their efficacy in treating acne.
dc.description.sponsorshipThis research received no external funding.
dc.identifier.doi10.3390/molecules29174234
dc.identifier.issn1420-3049
dc.identifier.issue17
dc.identifier.pmid39275081
dc.identifier.scopus2-s2.0-85203625921
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules29174234
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20780
dc.identifier.volume29
dc.identifier.wosWOS:001311088700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectacne
dc.subjectphenolics
dc.subjectEGCG
dc.subjectquercetin
dc.subjectnobiletin
dc.titlePlant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review
dc.typeReview Article

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