The single-step synthesis of thiol-functionalized phosphazene-based polymeric microspheres as drug carrier
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, new microspheres were successfully fabricated from pentaerythritol tetrakis(3-mercaptopropionate) as model monomer and hexachlorocyclotriphosphazene as crosslinker using a single-step via precipitation polymerization method. Trimethoprim was chosen as the model antibiotic drug for drug release and antimicrobial activity studies. The percent of drug loading and drug entrapment efficiency of the microspheres was calculated to be 0.85% and 42.2%. According to correlation coefficients, the release kinetic was found to be Higuchi kinetic model and the release mechanism was non-Fickian model for microspheres. The drug-loaded microspheres exhibited excellent bacterial inhibition against gram-positive (Staphylococcus aureusandBacillus subtilis) and gram-negative (Escherichia coli) bacteria.
Açıklama
Anahtar Kelimeler
Phosphazene, thiol, microspheres, drug release, antibacterial
Kaynak
Polymer-Plastics Technology and Materials
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
59
Sayı
17
