Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study

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dc.authoridSenbayrak, Seniha/0000-0002-4983-6613
dc.authoridKart Yasar, Kadriye/0000-0003-2963-4894
dc.authoridGencer, Serap/0000-0002-3217-6305
dc.authoridINAL, AYSE SEZA/0000-0002-1182-7164
dc.authoridCivljak, Rok/0000-0001-8766-7438
dc.authoridPehlivanoglu, Filiz/0000-0001-9943-6004
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.contributor.authorCag, Yasemin
dc.contributor.authorOzturk-Engin, Derya
dc.contributor.authorGencer, Serap
dc.contributor.authorHasbun, Rodrigo
dc.contributor.authorSengoz, Gonul
dc.contributor.authorCrisan, Alexandru
dc.contributor.authorCeran, Nurgul
dc.date.accessioned2025-01-27T20:20:20Z
dc.date.available2025-01-27T20:20:20Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAims: There is no report on the factors affecting the resolution of symptoms related to meningitis during treatment of tuberculous meningitis (TBM). Thus, we examined the factors associated with early therapeutic responses. Materials and Methods: This multicenter study included 507 patients with microbiologically confirmed TBM. However, 94 patients eligible for the analysis were included in this study from 24 centers. Six out of 94 patients died and the statistical analysis was performed with 88 survivors. Early and late responder groups were compared in the statistical analysis. P < 0.05 were considered to show a significant difference. Results: In the multivariate analysis, the presence of vasculitis (P = 0.029, OR = 10.491 [95% CI, 1.27u86.83]) was found to be significantly associated with a delayed fever response whereas hydrocephalus was associated with altered mental status for 9 days duration (P = 0.005, OR = 5.740 [95% CI, 1.68u19.57]). According to linear regression analysis, fever was significantly persisting (7 days) in the presence of vasculitis (17.5 vs. 7, P< 0.001) and hydrocephalus (11 vs. 7, P = 0.029). Hydrocephalus was significantly associated with persisting headache (21 vs. 12, P = 0.025), delayed recovery of consciousness (19.5 vs. 7, P = 0.001), and a delay in complete recovery (21 vs. 14, P = 0.007) in the linear regression analysis. Following institution of treatment, the complaints seemed to disappear in up to 2 weeks among TBM survivors. Conclusions: In the absence of hydrocephalus or vasculitis, one week of anti-tuberculosis treatment seems to be adequate for the resolution of TBM symptoms. Hydrocephalus and vasculitis delay the resolution of TBM symptoms in response to antimycobacterial treatment.
dc.identifier.doi10.4103/0028-3886.190258
dc.identifier.endpage905
dc.identifier.issn0028-3886
dc.identifier.issn1998-4022
dc.identifier.issue5
dc.identifier.pmid27625226
dc.identifier.scopus2-s2.0-84988662394
dc.identifier.scopusqualityQ3
dc.identifier.startpage896
dc.identifier.urihttps://doi.org/10.4103/0028-3886.190258
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21668
dc.identifier.volume64
dc.identifier.wosWOS:000384527500014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNeurology India
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectClinical
dc.subjectmeningitis
dc.subjectresponse
dc.subjecttuberculosis
dc.titleHydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study
dc.typeArticle

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