Enhancing curcumin's efficacy with zinc oxide nanoparticles: A dynamic duo in combatting disease

Basit Öğe Kaydı
dc.authorid0000-0003-4056-1673
dc.contributor.authorNejabat, Mojgan
dc.contributor.authorHadizadeh, Farzin
dc.contributor.authorKarav, Sercan
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2026-02-03T12:02:43Z
dc.date.available2026-02-03T12:02:43Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe combination of Zinc Oxide Nanoparticles (ZnO NPs) and Curcumin (Cur) has garnered significant attention due to its therapeutic potential (e. g., cancer treatment, wound healing, and antioxidant applications). CUR has been highly regarded as a natural compound with pharmacological properties such as anticancer, antimicrobial, and antioxidant effects; however, its clinical applications are limited due to its low solubility and bioavailability. In this review, the potentials of CUR and ZnO NPs in the case of biomedical applications were taken into consideration. There have been many attempts to integrate ZnO NPs and CUR for enhancing the mentioned drawbacks of CUR. The effectiveness of ZnO-Cur (CUR/ZnO NPs) nanocomposites, particularly in cancer therapies has been very promising. These nanocomposites exhibit selective toxicity towards cancer cells, with their pH-sensitive release mechanism proving advantageous in targeting the acidic tumor microenvironment. In addition to these effects, CUR/ZnO NPs have antioxidant activity, induce apoptosis in cancer cells, and promote wound healing. The use of ZnO and ZnO-Cur composites led to notable improvements across various applications such as osteoblast viability increased by approximately 60%, Cur release improved by 150%, and osteosarcoma inhibition enhanced by 300%. In agricultural use, ZnO NPs increased silybin content and plant yield while sperm cryopreservation studies showed improved post-thaw quality with ZnO-Cur by measurable margins, significantly. The role of ZnO in boosting Cur bioavailability, therapeutic efficacy, and targeted delivery potential have been confirmed in several studies. However, there are many unsolved challenges such as scalability, cytotoxicity data, and toxicity at higher concentrations that need to be addressed.
dc.identifier.doi10.1016/j.ijpharm.2025.125889
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid40562286
dc.identifier.scopus2-s2.0-105009278908
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2025.125889
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34844
dc.identifier.volume681
dc.identifier.wosWOS:001526914600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectZnO NPs
dc.subjectCurcumin
dc.subjectCancer therapy
dc.subjectAntioxidant
dc.subjectNanocomposite
dc.titleEnhancing curcumin's efficacy with zinc oxide nanoparticles: A dynamic duo in combatting disease
dc.typeReview

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu