HDL-cholesterol is associated with systemic inflammation in cardiac syndrome X

Basit Öğe Kaydı
dc.authoridYontar, Osman Can/0000-0002-0099-8654
dc.authoridAydin, Ufuk/0000-0002-4083-6211
dc.authoridTENEKECIOGLU, ERHAN/0000-0003-4376-2833
dc.contributor.authorTenekecioglu, E.
dc.contributor.authorYilmaz, M.
dc.contributor.authorDemir, S.
dc.contributor.authorBekler, A.
dc.contributor.authorOzluk, O. A.
dc.contributor.authorAydin, U.
dc.contributor.authorGoncu, T.
dc.date.accessioned2025-01-27T20:35:13Z
dc.date.available2025-01-27T20:35:13Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim. Microvascular inflammation is associated with cardiac syndrome X (CSX). High-density lipoprotein cholesterol (HDL-C) reveals antiatherogenic features with stimulating endothelial NO production, inhibiting oxidative stress and vascular inflammation. We investigated relationship between HDL-C and inflammatory markers in CSX. Methods. Hundred patients with CSX and control group of 80 subjects were evaluated. Hematologic indices, lipid levels and C-reactive protein (CRP) levels were studied in patients underwent coronary angiography. Results. CRP levels were higher in CSX group than control group (4.59 +/- 3.82 mg/dL vs. 2.48 +/- 1.32 mg/dL, P<0.001). HDL-C was significantly lower in CSX group compared to control group (36.5 +/- 4.0 mg/dL vs. 47.5 +/- 12.7 mg/dL, P=0.008). White blood cell (WBC) count was higher in CSX group than in control group. Neutrophil-lymphocyte ratio (NLR) was found significantly increased in CSX group as compared to control group. On multivariate linear regression, lower HDL-C was found to be a significant predictor of higher NLR in patients with CSX independent from other clinical and biochemical variables. Conclusion. Lower HDL-C is associated with systemic inflammation in CSX. In patients with typical angina and normal epicardial coronaries,HDL-C and inflammatory markers should be investigated; one of the goals of treatment should be raising HDL-C.
dc.identifier.endpage141
dc.identifier.issn0026-4806
dc.identifier.issn1827-1669
dc.identifier.issue3
dc.identifier.pmid25028863
dc.identifier.scopus2-s2.0-84970998785
dc.identifier.scopusqualityQ1
dc.identifier.startpage133
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23600
dc.identifier.volume106
dc.identifier.wosWOS:000360186800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofMinerva Medica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMicrovascular angina
dc.subjectInflammation
dc.subjectDyslipidemias
dc.titleHDL-cholesterol is associated with systemic inflammation in cardiac syndrome X
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu