Chronic low back pain and exercise: a molecular perspective on aerobic and anaerobic core training

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dc.authorid0000-0002-1040-3255
dc.contributor.authorAykora, Emrah
dc.contributor.authorAkar, Ali
dc.contributor.authorEroglu, Huseyin Avni
dc.date.accessioned2026-02-03T12:03:00Z
dc.date.available2026-02-03T12:03:00Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChronic low back pain (CLBP) remains a significant challenge for clinicians, and a substantial percentage of adults experience it at some point in their lives. Non-pharmacological treatments have gained attention for managing pain through aerobic and anaerobic core exercises. However, studies on humans and animals have yielded conflicting results regarding the type of exercise and its effect on pain sensation. The pain sensitivity of CLBP patients largely depends on their physiological and psychological conditions. The most studied and supported non-drug treatments for managing CLBP are aerobic core workouts. Recently, new research has also shown promising benefits of anaerobic core exercises, which can help reduce discomfort. Both aerobic and core anaerobic exercises have distinct yet complementary roles in managing CLBP. Aerobic training enhances overall health and endurance, while core anaerobic exercises focus on stabilization and muscular support. Understanding how they work individually and together can help create more effective, personalized exercise plans for long-term CLBP management. These exercises are especially effective in correcting postural issues and lowering mechanical stress on the lumbar spine. Although the exact mechanisms are still unknown, both types of exercises have the potential to lessen pain. This scoping review discusses the pathophysiological processes and exercise-induced hypoalgesia related to CLBP therapy. Additionally, it explores the pain-related molecular mechanisms associated with both aerobic and anaerobic core exercises.
dc.identifier.doi10.1007/s11033-025-10895-4
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1
dc.identifier.pmid40751822
dc.identifier.scopus2-s2.0-105012498610
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11033-025-10895-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34931
dc.identifier.volume52
dc.identifier.wosWOS:001541871400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectLow back pain
dc.subjectHypoalgesia
dc.subjectHyperalgesia
dc.subjectPain management
dc.subjectAerobic exercise
dc.subjectAnaerobic exercise
dc.subjectCore exercise
dc.subjectDRG neurons
dc.subjectPain signaling pathways
dc.titleChronic low back pain and exercise: a molecular perspective on aerobic and anaerobic core training
dc.typeReview

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