Biotechnological production of prostaglandin

Basit Öğe Kaydı
dc.authoridYılmaz, Emin/0000-0003-1527-5042
dc.contributor.authorYilmaz, E
dc.date.accessioned2025-01-27T20:14:27Z
dc.date.available2025-01-27T20:14:27Z
dc.date.issued2001
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractProstaglandins (PGs) are the oxidation products of PG endoperoxide (PGH) synthase and other tissue enzvt-nes. They occur in a tissue-specific manner and act as local hormones. Biotechnological production of PGs has been of interest, but not yet fully established. Biological tissues have been used as PG sources, but this disturbs ecological balance, and the cost of production is very high for commercial purposes. On the other hand, various microorganisms have been shown to synthesize them de novo, or biotransform precursors to active molecules, but these processes have not been further evaluated. Using mammalian enzymes in free or immobilized form is a promising new approach to synthesize PG from fatty acid substrates. Rapid enzyme inactivation during the catalysis is the main problem to be solved. Optimization of factors in the reactions and the design of special reactors that will allow removal of products continuously from the reaction medium without affecting enzyme activity need immediate attention from researchers and the pharmaceutical industry. (C) 2001 Elsevier Science Inc. All rights reserved.
dc.identifier.doi10.1016/S0734-9750(01)00072-6
dc.identifier.endpage397
dc.identifier.issn0734-9750
dc.identifier.issue5
dc.identifier.pmid14538074
dc.identifier.scopus2-s2.0-0034873234
dc.identifier.scopusqualityQ1
dc.identifier.startpage387
dc.identifier.urihttps://doi.org/10.1016/S0734-9750(01)00072-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21099
dc.identifier.volume19
dc.identifier.wosWOS:000171011800003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofBiotechnology Advances
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectprostaglandin
dc.subjectbiotechnology
dc.subjectmicroorganism
dc.subjectenzyme
dc.subjectproduction
dc.titleBiotechnological production of prostaglandin
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu