The Investigation of the Effect of Ozone Therapy on Gout in Experimental Rat Models

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dc.authoridMAKAV, MUSTAFA/0000-0003-1879-8180
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorBilge, Ali
dc.contributor.authorTuysuz, Murat
dc.contributor.authorOzturk, Omur
dc.contributor.authorAdali, Yasemen
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorMakav, Mustafa
dc.contributor.authorAtilla Uslu, Gozde
dc.date.accessioned2025-01-27T20:24:22Z
dc.date.available2025-01-27T20:24:22Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe effect of ozone treatment in experimental rat gout arthritis was investigated. Twenty adult albino male rats were divided into 4 groups: Group 1 (Control) was followed without any medication, Group 2 (Gout control) was injected with a single dose of 0.2 mL (10 mg) monosodium urate (MSU) intraarticulary to 1st metatarsophalangeal joint to create experimental Gouty arthritis. Group 3 (Gout + Ozone) was injected intraarticulary to 1st metatarsophalangeal joint with a single dose of 0.2 mL (10 mg) MSU to generate experimental gout, followed by ozone therapy to the rats a single dose of 1 mL (10 mu g/mL) intraperitoneally daily for 3 weeks. The Group 4 (Ozone control) ozone therapy was given a single dose of 1 mL (10 mu g/mL) intraperitoneally daily for 3 weeks without gout formation. The results were recorded and compared statistically between the groups. In conclusion, the low level of inflammation in the third group (Gout + Ozone) was considered statistically significant as compared to the second group. With Ozone treatment the gout joint has been shown to have reduced acute inflammation, it has not been affected by the chronic proliferation process.
dc.identifier.doi10.9775/kvfd.2018.20793
dc.identifier.endpage249
dc.identifier.issn1300-6045
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85060908421
dc.identifier.scopusqualityQ3
dc.identifier.startpage245
dc.identifier.urihttps://doi.org/10.9775/kvfd.2018.20793
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22181
dc.identifier.volume25
dc.identifier.wosWOS:000455022100015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectGout
dc.subjectOzone
dc.subjectImmunomodulators
dc.subjectAnti-inflammatory agents
dc.titleThe Investigation of the Effect of Ozone Therapy on Gout in Experimental Rat Models
dc.title.alternativeDeneysel olarak gut oluşturulmuş ratlarda ozon terapinin etkisi
dc.typeArticle

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