Repurposing ivermectin: a new hope for glioblastoma multiforme?

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dc.authorid0000-0003-3864-0620
dc.contributor.authorMohtashami, Elmira
dc.contributor.authorBibak, Bahram
dc.contributor.authorSanati, Mehdi
dc.contributor.authorAfshari, Sadaf
dc.contributor.authorKahkhaie, Kolsoum Rezaie
dc.contributor.authorVahedi, Mohammad Mahdi
dc.contributor.authorJalili-Nik, Mohammad
dc.date.accessioned2026-02-03T12:03:08Z
dc.date.available2026-02-03T12:03:08Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIvermectin is the most extensively researched macrocyclic lactone due to its potential anticancer and antiparasitic use. Nonetheless, there are more compounds within this family, including doramectin and abamectin. In the current era of medicinal repurposing, ivermectin has received renewed focus following its initial development for the treatment of parasitic conditions such as scabies, elephantiasis, and river blindness. Recent studies indicate that ivermectin may inhibit the proliferation of specific tumor cells by regulating many signaling pathways implicated in cancer progression. Despite the growing body of research on the topic, critical issues about its anticancer processes remain unresolved. Our study focused on ivermectin, its mechanisms of action, and its potential uses against glioblastoma multiforme (GBM).
dc.identifier.doi10.1007/s00044-025-03435-z
dc.identifier.endpage1615
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue8
dc.identifier.scopus2-s2.0-105009437627
dc.identifier.scopusqualityQ1
dc.identifier.startpage1603
dc.identifier.urihttps://doi.org/10.1007/s00044-025-03435-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34985
dc.identifier.volume34
dc.identifier.wosWOS:001520016700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Birkhauser
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectMacrocyclic lactone
dc.subjectIvermectin
dc.subjectAntiproliferative
dc.subjectAnticancer
dc.subjectGlioblastoma multiforme
dc.titleRepurposing ivermectin: a new hope for glioblastoma multiforme?
dc.typeReview

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