Effect of Prebiotic-Added Foods on Infant Health: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Basit Öğe Kaydı
dc.contributor.authorTanriverdi, Dogan Cagri
dc.contributor.authorKaraahmet, Aysu Yildiz
dc.contributor.authorBilgic, Fatma Sule
dc.date.accessioned2026-02-03T12:00:10Z
dc.date.available2026-02-03T12:00:10Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In cases where breastfeeding is not possible, one of the recommended strategies to change the composition of the nutritional baby's gut microbiota and bring it closer to breastfed infants is to enrich the infant's food with prebiotics. The aim of this study was to systematically review the results of its effect on growth, gait and gastrointestinal (GI) system in infants fed with prebiotic-added formula and to perform a meta-analysis of the available evidence. Materials and Methods: The literature review for this systematic review was conducted between January and February 2023 using five electronic databases: PubMed, CINAHL, Scopus, WOS and ULAKB & Idot;M. Articles were scanned using MeSH-based keywords. Only Randomized Controlled Trials conducted in the last five years were included. The data were analyzed using the Review Manager computer program (Version 5.3). Results: The analysis included six studies involving 1399 formula-fed infants. In the post-intervention analysis of the included studies, there were no significant differences in weight (SMD: -0.21 95% CI: -0.45 to 0.03, Z=1.68, p=0.09), stool frequency (SMD:0.34 95% CI:-2. 89 to 3.58, Z=4.58, p=0.84), but there was a significant difference in the stool consistency (SMD:-0.50 95% CI:-0.73 to-0.27, Z=4.24, p<0.00001). Conclusion: This systematic review and meta-analysis confirmed that prebiotic-enriched infant formulas are likely to provide benefits for healthy infants. The studies indicate that the inclusion of prebiotics in formulas improves stool consistency. However, no significant effects were found on growth or stool frequency. These findings suggest that further research is needed to better understand the effects of prebiotics on infant gastrointestinal health.
dc.identifier.doi10.26650/jchild.2025.1583034
dc.identifier.endpage9
dc.identifier.issn1308-8491
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.26650/jchild.2025.1583034
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34535
dc.identifier.volume25
dc.identifier.wosWOS:001539419000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherIstanbul Univ
dc.relation.ispartofJournal of Child - Cocuk Dergisi
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectPrebiotics
dc.subjectformula
dc.subjectnewborn
dc.subjectanthropometric
dc.subjectgastrointestinal symptoms
dc.titleEffect of Prebiotic-Added Foods on Infant Health: A Systematic Review and Meta-analysis of Randomized Controlled Trials
dc.typeReview

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu