The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model

Basit Öğe Kaydı
dc.contributor.authorErcan, Umut
dc.contributor.authorKiraz, Asli
dc.contributor.authorCikman, Oztekin
dc.contributor.authorTurkon, Hakan
dc.contributor.authorKilinc, Nihal
dc.contributor.authorOtkun, Muserref Tatman
dc.contributor.authorOzkan, Omer Faruk
dc.date.accessioned2025-01-27T20:53:51Z
dc.date.available2025-01-27T20:53:51Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats.Materials and Methods: A total of 40 Sprague-Dawley rats were used. The rats were randomly divided into four groups of 10 (n = 10). Groups 1 and 2 had laparotomy and colon anastomosis performed. Groups 3 and 4 had cecal ligation and puncture (CLP) and colon anastomosis performed. Rats in Groups 1 and 3 were given 15mL/kg intraperitoneal 0.9% isotonic NaCl, while the rats in Groups 2 and 4 were given 100mg/kg intraperitoneal L-carnitine. On the postoperative fifth day, the rats were sacrificed and the burst pressure of anastomosis, histopathological effects, and tissue hydroxyproline levels were investigated.Results: In Groups 2 and 4, the anastomosis burst pressure and histopathological results in both noninfected abdomen and presence of peritonitis were statistically high compared to the control group (p < 0.05). Though the hydroxyproline levels were also high, there was no statistically significant difference for this parameter (p > 0.05).Conclusions: The findings obtained from the experimental sepsis model showed that healing of anastomosis in both the presence of peritonitis and noninfected abdomen was positively affected by the systemic administration of L-carnitine and this may contribute to the safety of anastomosis.
dc.identifier.doi10.3109/08941939.2015.1029652
dc.identifier.endpage340
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6
dc.identifier.pmid26270147
dc.identifier.scopus2-s2.0-84951574014
dc.identifier.scopusqualityQ1
dc.identifier.startpage334
dc.identifier.urihttps://doi.org/10.3109/08941939.2015.1029652
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25868
dc.identifier.volume28
dc.identifier.wosWOS:000366322100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcolon anastomosis
dc.subjectanastomosis healing
dc.subjectcecal ligation and puncture
dc.subjectsepsis
dc.subjectL-carnitine
dc.titleThe Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu