Prevalence of MASLD and Fibrosis Risk in Turkish Adults with Cardiometabolic Risk Factors: A Nationwide Multicenter Study (DAHUDER MASLD Study)

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dc.authorid0000-0002-7577-5084
dc.authorid0000-0001-9870-509X
dc.authorid0009-0008-2892-5319
dc.authorid0000-0001-6726-1502
dc.authorid0000-0002-6341-947X
dc.authorid0000-0003-4990-4927
dc.authorid0009-0000-9064-4982
dc.contributor.authorKirik, Ali
dc.contributor.authorSumbul, Hilmi Erdem
dc.contributor.authorKoca, Nizameddin
dc.contributor.authorKilit, Turkan Pasali
dc.contributor.authorSezer, Sibel Demiral
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorArac, Esref
dc.date.accessioned2026-02-03T11:59:53Z
dc.date.available2026-02-03T11:59:53Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence data in Turkiye is limited. We aimed to determine the nationwide prevalence of MASLD and advanced hepatic fibrosis risk in subjects with cardiometabolic risk factors (CMRF). Despite recent international consensus redefining fatty liver disease terminology, no nationwide MASLD study has been reported in Turkiye. Methods: This cross-sectional study included 14,371 adults with >= 1 CMRF from 44 centers across 31 cities. MASLD was diagnosed using liver ultrasonography plus cardiometabolic criteria. Advanced fibrosis risk was assessed by fibrosis-4 (FIB-4) score (>= 1.3 for <= 65 years; >= 2.0 for >65 years). Logistic regression was used to identify independent predictors of high FIB-4. Results: A total of 61.4% of participants were women, the mean age was 51.3 +/- 14.4 years, and the mean BMI was 31.4 +/- 6.0 kg/m(2). MASLD prevalence was 75.7% (n = 10,873), rising with the number of CMRFs (56.5% with one factor vs. 83.4% with all). The prevalence of high FIB-4 scores was 12.0% overall, being lower in MASLD patients than non-MASLD patients (11.2% vs. 14.4%, p < 0.001). FIB-4 scores decreased with increasing BMI (28.1% underweight vs. 8.7% class III obesity). Male sex, T2DM, and hypertension independently predicted high FIB-4 scores, while smoking, higher BMI, and MASLD were inversely associated. Conclusions: Three-quarters of Turkish adults with CMRF have MASLD. Standard FIB-4 thresholds may underestimate fibrosis risk in obese and smoking populations, underscoring the need for adjusted cut-offs or alternative tools. This study is the first to provide nationwide MASLD prevalence data in Turkiye.
dc.description.sponsorshipRecep Tayyip Erdoan University Development Foundation [02025008018696]
dc.description.sponsorshipThis study was supported through a grant (number 02025008018696) from the Recep Tayyip Erdoan University Development Foundation.
dc.identifier.doi10.3390/jcm14197098
dc.identifier.issn2077-0383
dc.identifier.issue19
dc.identifier.pmid41096179
dc.identifier.scopus2-s2.0-105020048069
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14197098
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34449
dc.identifier.volume14
dc.identifier.wosWOS:001639401000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectMASLD
dc.subjectobesity
dc.subjecthypertension
dc.subjecttype 2 diabetes mellitus
dc.subjectliver fibrosis
dc.subjectFIB-4 score
dc.titlePrevalence of MASLD and Fibrosis Risk in Turkish Adults with Cardiometabolic Risk Factors: A Nationwide Multicenter Study (DAHUDER MASLD Study)
dc.typeArticle

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