The incidence and severity of pulmonary hypertension in obstructive sleep apnea with hypothyroidism

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dc.authoridAcemoglu, Hamit/0000-0002-4667-8103
dc.authoridAkgun, Metin/0000-0003-3404-4274
dc.contributor.authorAraz, Omer
dc.contributor.authorUcar, Elif Yilmazel
dc.contributor.authorYalcin, Aslihan
dc.contributor.authorPulur, Didem
dc.contributor.authorAcemoglu, Hamit
dc.contributor.authorTas, Hakan
dc.contributor.authorSaglam, Leyla
dc.date.accessioned2025-01-27T21:02:00Z
dc.date.available2025-01-27T21:02:00Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Hypothyroidism and obstructive sleep apnea (OSA) are both common health problems and can be seen together. Each of these 2 diseases can cause pulmonary hypertension (PH). We aimed to determine whether hypothyroidism with OSA has a significant effect on the frequency and severity of PH. Material/Methods: A total of 236 patients were included in the study. Patients were divided into 3 groups: Group I, Obstructive Sleep Apnea (n=149); Group II, Hypothyroidism (n=56); and Group III, Obstructive Sleep Apnea-Hypothyroidism (n=31). All patients underwent polysomnography and echocardiography and serum levels of thyroid-stimulating hormone (TSH) and free thyroxine 4 (FT4) were analyzed. Results: There were 167 male and 69 female participants, and the mean age was 47.8 +/- 11.5 (Group I: 81.9% male, 18.1% female; Group II: 44.6% male, 55.4% female; Group III: 64.6% male, 35.4% female). Distribution of mean pulmonary arterial pressure on echocardiography was statistically different among the 3 groups (x(2)=14.99, p=0.006). When adjusted according to the apnea-hypopnea index (AHI), age, and body mass index (BMI), a significant relation with PH was determined (p=0.002). Conclusions: The combination of hypothyroidism with OSA is associated with an increased frequency and severity of PH. When PH is found out of line with the severity of OSA, thyroid dysfunction should be investigated.
dc.identifier.endpage887
dc.identifier.issn1643-3750
dc.identifier.pmid24149072
dc.identifier.scopus2-s2.0-84886246036
dc.identifier.scopusqualityQ1
dc.identifier.startpage883
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27254
dc.identifier.volume19
dc.identifier.wosWOS:000325967500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Scientific Literature, Inc
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectobsttructive sleep apnea
dc.subjecthypothyroidism
dc.subjectpulmonary hypertension
dc.titleThe incidence and severity of pulmonary hypertension in obstructive sleep apnea with hypothyroidism
dc.typeArticle

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