Temperature and magnetic field responsive hyaluronic acid particles with tunable physical and chemical properties

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dc.authoridYılmaz, Selehattin / 0000-0003-4607-3523
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridEkici, Sema / 0000-0001-9940-8388
dc.authoridIlgın, Pınar / 0000-0001-7071-0575
dc.contributor.authorEkici, Sema
dc.contributor.authorIlgın, Pınar
dc.contributor.authorYılmaz, Selahattin
dc.contributor.authorAktaş, Nahit
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:38:40Z
dc.date.available2025-01-27T20:38:40Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe report the preparation and characterization of thiolated-temperature-responsive hyaluronic acid-cysteamine-N-isopropyl acrylamide (HA-CYs-NIPAm) particles and thiolated-magnetic-responsive hyaluronic acid (HA-Fe-CYs) particles. Linear hyaluronic acid (HA) crosslinked with divinyl sulfone as HA particles was prepared using a water-in-oil micro emulsion system which were then oxidized HA-O with NaIO4 to develop aldehyde groups on the particle surface. HA-O hydrogel particles were then reacted with cysteamine (CYs) which interacted with aldehydes on the HA surface to form HA particles with cysteamine (HA-CYs) functionality on the surface. HA-CYs particles were further exposed to radical polymerization with NIPAm to obtain temperature responsive HA-CYs-NIPAm hydrogel particles. To acquire magnetic field responsive HA composites, magnetic iron particles were included in HA to form HA-Fe during HA particle preparation. HA-Fe hydrogel particles were also chemically modified. The prepared HA-CYs-NIPAm demonstrated temperature dependent size variations and phase transition temperature. HA-CYs-NIPAm and HA-Fe-CYs particles can be used as drug delivery vehicles. Sulfamethoxazole (SMZ), an antibacterial drug, was used as a model drug for temperature-induced release studies from these particles. (C) 2010 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Council of Turkey [108T133]; Turkish Academy of Science
dc.description.sponsorshipThis work is supported by the Scientific and Technological Council of Turkey (grant no: 108T133). Also, N. Sahiner greatly appreciates financial support from the Turkish Academy of Science under the TUBA-GEBIP Program 2008.
dc.identifier.doi10.1016/j.apsusc.2010.10.040
dc.identifier.endpage2676
dc.identifier.issn0169-4332
dc.identifier.issn1873-5584
dc.identifier.issue7
dc.identifier.scopus2-s2.0-79251598944
dc.identifier.scopusqualityQ1
dc.identifier.startpage2669
dc.identifier.urihttps://doi.org/10.1016/j.apsusc.2010.10.040
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23696
dc.identifier.volume257
dc.identifier.wosWOS:000285963200044
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofApplied Surface Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTemperature-sensitive HA particles
dc.subjectMagnetic composite
dc.subjectDrug release
dc.subjectModifiable HA particles
dc.titleTemperature and magnetic field responsive hyaluronic acid particles with tunable physical and chemical properties
dc.typeArticle

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