Biopsy-proven BK virus nephropathy in renal transplant recipients: A multi-central study from Turkey (BK-TURK STUDY)

Basit Öğe Kaydı
dc.contributor.authorGungor, Ozkan
dc.contributor.authorDheir, Hamad
dc.contributor.authorIslam, Mahmud
dc.contributor.authorToz, Huseyin
dc.contributor.authorYildiz, Abdulmecit
dc.contributor.authorSinangil, Ayse
dc.contributor.authorTatar, Erhan
dc.date.accessioned2025-01-27T20:52:15Z
dc.date.available2025-01-27T20:52:15Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: BK polyomavirus infection is a challenging complication of renal transplantation. The management is not standardized and is based on reports from transplantation centers' experiences, usually with small sample sizes. Therefore, we aimed to present our countrywide experience with BK virus nephropathy (BKVN) in renal transplant recipients. Materials and methods: Our study was carried out with the participation of 30 transplantation centers from all regions of Turkey. Only cases with allograft biopsy-proven BKVN were included in the study. Results: 13,857 patients from 30 transplantation centers were screened, and 207 BK nephropathy cases were included. The mean age was 46.4 +/- 13.1 years, and 146 (70.5%) patients were male. The mean time to diagnosis of BK nephropathy was 15.8 +/- 22.2 months after transplantation. At diagnosis, the mean creatinine level was 1.8 +/- 0.7 mg/dL, and the mean estimated glomerular filtration rate was 45.8 +/- 19.6 mL/min/1.73m2. 2 . In addition to dose reduction or discontinuation of immunosuppressive drugs, 18 patients were treated with cidofovir, 11 patients with leflunomide, 17 patients with quinolones, 15 patients with intravenous immunoglobulin (IVIG), 5 patients with cidofovir plus IVIG, and 12 patients with leflunomide plus IVIG. None of the patients receiving leflunomide or leflunomide plus IVIG had allograft loss. During follow-up, allograft loss occurred in 32 (15%) out of 207 patients with BK nephropathy. Conclusion: BKVN is still a frequent cause of allograft loss in kidney transplantation and is not fully elucidated. The results of our study suggest that leflunomide treatment is associated with more favorable allograft outcomes.
dc.description.sponsorshipOrgan transplant is teamwork. There-fore, we would like to thank the transplant surgeons, pathologists, microbiologists, and interventional radiologists for their efforts in diagnosing and treating the patients we included in the study.
dc.identifier.doi10.5414/CN111300
dc.identifier.endpage211
dc.identifier.issn0301-0430
dc.identifier.issue4
dc.identifier.pmid39037084
dc.identifier.scopus2-s2.0-85205021979
dc.identifier.scopusqualityQ3
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.5414/CN111300
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25709
dc.identifier.volume102
dc.identifier.wosWOS:001277471800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDustri-Verlag Dr Karl Feistle
dc.relation.ispartofClinical Nephrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBK virus nephropathy
dc.subjectgraft dysfunction
dc.subjectgraft Loss
dc.subjectkidney biopsy
dc.subjectkidney transplantation
dc.titleBiopsy-proven BK virus nephropathy in renal transplant recipients: A multi-central study from Turkey (BK-TURK STUDY)
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu