Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

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dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.authoridDemir, Emin Tunc/0000-0002-6945-1091
dc.authoridKapicibasi, Hasan Oguz/0000-0001-7275-1039
dc.contributor.authorKapicibasi, Hasan Oguz
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorDemir, Emin Tunc
dc.contributor.authorAdali, Yasemen
dc.contributor.authorElmas, Sait
dc.date.accessioned2025-01-27T20:11:52Z
dc.date.available2025-01-27T20:11:52Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: This experimental sepsis model created with Escherichia coil aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2nd and 3rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters.
dc.identifier.doi10.1590/s0102-865020200060000004
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6
dc.identifier.pmid32667585
dc.identifier.scopus2-s2.0-85087881549
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s0102-865020200060000004
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20763
dc.identifier.volume35
dc.identifier.wosWOS:000550593600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectLung
dc.subjectOzone
dc.subjectSepsis
dc.subjectRats
dc.titlePulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model
dc.typeArticle

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