Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis

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dc.contributor.authorEdem, Efe
dc.contributor.authorReyhanoglu, Hasan
dc.contributor.authorKucukukur, Murat
dc.contributor.authorKirdok, Ali Hikmet
dc.contributor.authorKinay, Ahmet Ozan
dc.contributor.authorTekin, Umit Ilker
dc.contributor.authorOzcan, Kaan
dc.date.accessioned2025-01-27T20:22:55Z
dc.date.available2025-01-27T20:22:55Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Aortic valve stenosis (AVS) is the most common cause of left ventricular outflow obstruction, and its prevalence among elderly patients causes a major public health burden. Recently, platelet-to-lymphocyte ratio (PLR) has been recognized as a novel prognostic biomarker that offers information about both aggregation and inflammation pathways. Since PLR indicates inflammation, we hypothesized that PLR may be associated with the severity of AVS due to chronic inflammation pathways that cause stiffness and calcification of the aortic valve. Materials and Methods: We retrospectively enrolled 117 patients with severe degenerative AVS, who underwent aortic valve replacement and 117 control patients in our clinic. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. Severe AVS was defined as calcification and sclerosis of the valve with a mean pressure gradient of > 40 mmHg. Results: PLR was 197.03 +/- 49.61 in the AVS group and 144.9 +/- 40.35 in the control group, which indicated a statistically significant difference (P < 0.001). A receiver operating characteristic (ROC) curve analysis demonstrated that PLR values over 188 predicted the severity of aortic stenosis with a sensitivity of 87% and a specificity of 70% (95% confidence interval = 0.734- 0.882; P < 0.001; area under ROC curve: 0.808). Conclusion: We suggest that the level of PLR elevation is related to the severity of degenerative AVS, and PLR should be used to monitor patients' inflammatory responses and the efficacy of treatment, which will lead us to more closely monitor this high-risk population to detect severe degenerative AVS at an early stage.
dc.identifier.doi10.4103/1735-1995.192509
dc.identifier.issn1735-1995
dc.identifier.issn1735-7136
dc.identifier.pmid28163739
dc.identifier.scopus2-s2.0-84989352649
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.4103/1735-1995.192509
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22071
dc.identifier.volume21
dc.identifier.wosWOS:000387207000003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Research in Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAortic valve stenosis
dc.subjectbiomarkers
dc.subjectplatelets
dc.titlePredictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis
dc.typeArticle

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